TAILIEUCHUNG - A new flavonoid from ophiopogon confertifolius

From the methanolic extract of the roots of Ophiopogon confertifolius N. Tanaka (Convallariaceae) a new flavonoid named ophiofolius A (1) and two known compounds (2, 3) were isolated. Their structures were elucidated as 6,8-dimethyl-4’methoxy-5,7,3’,5’- tetrahydroxyflavanone (1), 6,8-dimethyl-3’,4’-dimethoxy-5,7,5’-trihydroxyflavanone (2), and 6- methoxy-5,7-dihydroxyflavanone (3) by the spectroscopic evidences (1D NMR, 2D NMR, ESI- MS). | Journal of Chemistry Vol. 45 6 P. 791 - 794 2007 A NEW FLAVONOID FROM OPHIOPOGON CONFERTIFOLIUS Received 2 July 2007 NGUYEN THI VINH HUE1 NGUYEN DUY THUAN2 NGUYEN TRONG THONG3 CHAU VAN MINH4 PHAN VAN KIEM4 J raphaco Joint Stock Company Ministry of Health 2National Institute of Medicinal Materials Ministry of Health 3Hanoi Medical University Ministry of Health 4Institute of Natural Products Chemistry VAST SUMMARY From the methanolic extract of the roots of Ophiopogon confertifolius N. Tanaka Convallariaceae a new flavonoid named ophiofolius A 1 and two known compounds 2 3 were isolated. Their structures were elucidated as 6 8-dimethyl-4 methoxy-5 7 3 5 tetrahydroxyflavanone 1 6 8-dimethyl-3 4 -dimethoxy-5 7 5 -trihydr oxy flavanone 2 and 6-methoxy-5 7-dihydroxyflavanone 3 by the spectroscopic evidences 1D NMR 2D NMR ESIMS . I - INTRODUCTION Cao cang is a traditional medicinal plant of the people who lives in some mountainous areas of Bac Giang province. It has been used to treat osteocopic pain dispel swelling and blood clotting in ecchymosis renal failure. The scientific name of this plant has been identified as Ophiopogon confertifolius N. Tanaka Convallariaceae . This is a new species of Vietnamese flora 1 . Up to date no studies on the chemical and bioactivities of this plant were carried out. As a part of our study on this plant we report herein the isolation and the structural elucidation of 8-dimethyl-4 methoxy-5 7 3 5 -tetrahydroxyflavanone 1 6 8-dimethyl-3 4 -dimethoxy-5 7 5 -trihydroxyflavanone 2 and 6-methoxy-5 7-dihydroxyflavanone 3 by the spectroscopic evidences 1D NMR 2D NMR ESI-MS . Compound 1 was isolated for the first time from nature and compounds 2 and 3 were first isolated from the Ophiopogon species. II - EXPERIMENTAL 1. Plant material The roots of Ophiopogon confertifolius N. Tanaka Convallariaceae were collected in Yen The Bac Giang province Vietnam and the plant was identified by Dr Nguyen Thi Do Institute of Ecology and Biological Resources

• Hoá học
• Công nghệ hóa
• A new flavonoid
• Ophiopogon confertifolius
• Hóa dược
• Plant material
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