TAILIEUCHUNG - Báo cáo khoa học: Diversity, taxonomy and evolution of medium-chain dehydrogenase/reductase superfamily

Acomprehensive, structural and functional, insilicoanalysis of the medium-chain dehydrogenase/reductase (MDR) superfamily, including 583 proteins, was carried out by use of extensive database mining and theBLASTPprogram in an iterative manner to identify all known members of the superfamily. Based on phylogenetic, sequence, and func-tional similarities, the protein members of the MDR super-family were classified into three different taxonomic categories: (a) subfamilies, consisting of a closed group containing a set of ideally orthologous proteins that perform the same function;. | Eur. J. Biochem. 270 3309-3334 2003 FEBS 2003 doi Diversity taxonomy and evolution of medium-chain dehydrogenase reductase superfamily Hector Riveros-Rosas1 Adriana Julian-Sanchez1 Rafael Villalobos-Molina2 Juan Pablo Pardo1 and Enrique Pina1 1Depto. Bioquimica Fac. Medicina UNAM Cd. Universitaria Mexico . Mexico 2Depto. Farmacobiologia ClNvESTAV-Sede Sur Mexico . Mexico A comprehensive structural and functional in silico analysis of the medium-chain dehydrogenase reductase MDR superfamily including 583 proteins was carried out by use of extensive database mining and the BLASTP program in an iterative manner to identify all known members of the superfamily. Based on phylogenetic sequence and functional similarities the protein members of the MDR superfamily were classified into three different taxonomic categories a subfamilies consisting of a closed group containing a set of ideally orthologous proteins that perform the same function b families each comprising a cluster of monophyletic subfamilies that possess significant sequence identity among them and might share or not common substrates or mechanisms of reaction and c macrofamilies each comprising a cluster of monophyletic protein families with protein members from the three domains of life which includes at least one subfamily member that displays activity related to a very ancient metabolic pathway. In this context a superfamily is a group of homologous protein families and or macrofamilies with monophyletic origin that shares at least a barely detectable sequence similarity but showing the same 3D fold. The MDR superfamily encloses three macrofamilies with eight families and 49 subfamilies. These subfamilies exhibit great functional diversity including noncatalytic members with different subcellular phylogenetic and species distributions. This results from constant enzymogenesis and proteinogenesis within each kingdom and highlights the huge plasticity that MDR .

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