TAILIEUCHUNG - Báo cáo khoa học: Modular usage of the HLA-DRA promoter in extra-hematopoietic and hematopoietic cell types of transgenic mice

Class II MHC genes (for example, the humanHLA-DRAgene) are expressed at the cell surface in many professional and nonprofessional anti-gen-presenting cells in a variety of anatomical locations. Here, we report about 13 mouse transgenic lines (11 of which have not been previously des-cribed) generated with four distinct sets of DRAtransgenes carrying pro-gressive, informative 5¢ and 3¢ deletions. | iFEBS Journal Modular usage of the HLA-DRA promoter in extra-hematopoietic and hematopoietic cell types of transgenic mice Ezio Giorda1 z Leonardo Sibilio1 Aline Martayan1 Giordana Feriotto2 Nicoletta Bianchi2 Carlo Mischiati3 Francesca Di Rosa4 Laura Pozzi5 Roberto Gambari2 6 and Patrizio Giacomini1 1 Laboratory of Immunology Regina Elena Cancer Institute CRS Rome Italy 2 ER-Gentech Biotechnology Center University of Ferrara Italy 3 Department of Biochemistry and Molecular Biology Molecular Biology Section University of Ferrara Italy 4 Institute of Genetics and Biophysics A. Buzzati-Traverso CNR Naples Italy 5 Telethon Transgenic Mouse Facilities Regina Elena Cancer Institute CRS Rome Italy 6 Interdisciplinary Center for the Study of Inflammation University of Ferrara Italy Keywords class II MHC gene regulation IFN-y transgenics Correspondence P. Giacomini Laboratory of Immunology Regina Elena Cancer Institute CRS Via delle Messi d Oro 156 00158 Rome Italy Fax 39 06 52662600 Tel 39 06 52662533 E-mail giacomini@ Present address Research Center Ospedale Bambino Gesu Rome Italy Received 3 March 2005 revised 20 April 2005 accepted 26 April2005 doi Class II MHC genes for example the human HLA-DRA gene are expressed at the cell surface in many professional and nonprofessional antigen-presenting cells in a variety of anatomical locations. Here we report about 13 mouse transgenic lines 11 of which have not been previously described generated with four distinct sets of DRA transgenes carrying progressive informative 5 and 3 deletions. DRA expression was assessed in B lymphocytes dendritic cells macrophages and extra-hematopoietic cells particularly kidney epithelial cells . A compact transcriptional unit was identified that efficiently directs DRA expression both constitutive and interferon IFN -c induced in extra-hematopoietic tissues and dendritic cells. It extends from position -266 upstream of the transcription initiation site to

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