TAILIEUCHUNG - Báo cáo khoa học: The protein shuffle Sequential interactions among components of the human nucleotide excision repair pathway

Xeroderma pigmentosum (XP) is an inherited disease in which cells from patients exhibit defects in nucleotide excision repair (NER). XP proteins A–G are crucial in the processes of DNA damage recognition and incision, and patients with XP can carry mutations in any of the genes that specify these proteins. | iFEBS Journal MINIREVIEW The protein shuffle Sequential interactions among components of the human nucleotide excision repair pathway Chin-Ju Park and Byong-Seok Choi Department of Chemistry NationalCreative Initiative Center Korea Advanced Institute of Science and Technology Guseong-dong Yuseong-gu Daejon Korea Keywords damage recognition dual incision nucleotide excision repair protein-protein interaction replication protein A structure xeroderma pigmentosa Correspondence . Choi Department of Chemistry National Creative Initiative Center Korea Advanced Institute of Science and Technology KAIST 373-1 Guseong-dong Yuseong-gu Daejon 305-701 Korea Fax 82 42 8692810 Tel 82 42 8692868 E-mail Received 12 December 2005 accepted 16 February 2006 doi Xeroderma pigmentosum XP is an inherited disease in which cells from patients exhibit defects in nucleotide excision repair NER . XP proteins A-G are crucial in the processes of DNA damage recognition and incision and patients with XP can carry mutations in any of the genes that specify these proteins. In mammalian cells NER is a dynamic process in which a variety of proteins interact with one another via modular domains to carry out their functions. XP proteins are key players in several steps of the NER process including DNA strand discrimination XPA in complex with replication protein A repair complex formation XPC in complex with hHR23B XPF in complex with ERCC1 and repair factor recruitment transcription factor IIH in complex with XPG . Through these protein-protein interactions various types of bulky DNA adducts can be recognized and repaired. Communication between the NER system and other cellular pathways is also achieved by selected binding of the various structural domains. Here we summarize recent studies on the domain structures of human NER components and the regulatory networks that utilize these proteins. Data provided by these studies have helped .

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