TAILIEUCHUNG - Báo cáo khoa học: Nanoparticle–enzyme hybrid systems for nanobiotechnology

Biomolecule–nanoparticle (NP) [or quantum-dot (QD)] hybrid systems combine the recognition and biocatalytic properties of biomolecules with the unique electronic, optical, and catalytic features of NPs and yield com-posite materials with new functionalities. | MINIREVIEW Nanoparticle-enzyme hybrid systems for nanobiotechnology Itamar Willner Bernhard Basnar and Bilha Willner Institute of Chemistry The Hebrew University of Jerusalem Israel Keywords enzymes nanoparticles nanowires quantum dots semiconductors Correspondence I. Willner Institute of Chemistry The Hebrew University of Jerusalem 91904 Jerusalem Israel Fax 972 2 6527715 Tel 972 2 6585272 E-mail willnea@ Received 5 October 2006 accepted 20 November 2006 doi Biomolecule-nanoparticle NP or quantum-dot QD hybrid systems combine the recognition and biocatalytic properties of biomolecules with the unique electronic optical and catalytic features of NPs and yield composite materials with new functionalities. The biomolecule-NP hybrid systems allow the development of new biosensors the synthesis of metallic nanowires and the fabrication of nanostructured patterns of metallic or magnetic NPs on surfaces. These advances in nanobiotechnology are exemplified by the development of amperometric glucose sensors by the electrical contacting of redox enzymes by means of AuNPs and the design of an optical glucose sensor by the biocatalytic growth of AuNPs. The biocata-lytic growth of metallic NPs is used to fabricate Au and Ag nanowires on surfaces. The fluorescence properties of semiconductor QDs are used to develop competitive maltose biosensors and to probe the biocatalytic functions of proteases. Similarly semiconductor NPs associated with electrodes are used to photoactivate bioelectrocatalytic cascades while generating photocurrents. Introduction Biomolecules such as proteins antibodies antigens and DNA exhibit comparable dimensions to metallic or semiconductor nanoparticles NPs . Thus by integrating biomolecules and NPs into hybrid conjugates new functional chemical entities that combine the unique electronic optical and catalytic properties of metallic or semiconductor NPs with the unique recognition and catalytic properties

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