TAILIEUCHUNG - Báo cáo khoa học: Molecular events during leukocyte diapedesis

The recruitment of leukocytes from the circulation into tissues requires leu-kocyte migration through the vascular endothelium. The mechanisms by which leukocytes attach and firmly adhere to the endothelial cell surface have been studied in detail. However, much less is known about the last step in this process, the diapedesis of leukocytes through the vascular endo-thelium. | ỊFEBS Journal MINIREVIEW Molecular events during leukocyte diapedesis Bjorn Petri1 and M. Gabriele Bixel1 2 1 Max-Planck-Institute of Molecular Biomedicine Munster Germany 2 Institute of Cell Biology Center for Molecular Biology of Inflammation ZMBE Munster Germany Keywords diapedesis extravasation leukocyte paracellular transcellular Correspondence M. G. Bixel Max-Planck Institute of Molecular Biomedicine Institute of Cell Biology Rontgenstr. 20 48149 Muenster Germany Fax 49 251 8352236 Tel 49 251 8352177 E-mail mgbixel@ Received 15 May 2006 revised 16 July 2006 accepted 17 July 2006 doi The recruitment of leukocytes from the circulation into tissues requires leukocyte migration through the vascular endothelium. The mechanisms by which leukocytes attach and firmly adhere to the endothelial cell surface have been studied in detail. However much less is known about the last step in this process the diapedesis of leukocytes through the vascular endothelium. This minireview focuses on the interactions between leukocyte and endothelial cell adhesion molecules that are important during leukocyte extravasation. In the past few years a series of endothelial cell surface and adhesion molecules have been identified that are located at endothelial cell contacts and found to participate in leukocyte diapedesis. These junctional cell adhesion molecules are believed to have an active role in controlling the opening and closure of endothelial cell contacts to allow the passage of leukocytes between adjacent endothelial cells. Alternatively leukocytes can cross the endothelium at nonjunctional locations with leukocytes migrating through a single endothelial cell. Further work is clearly needed to understand in greater detail the molecular mechanisms that allow leukocytes to cross the endothelium via either the paracellular or the transcellular pathway. Migration of blood leukocytes to sites of injury or infection is crucial in .

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