TAILIEUCHUNG - Báo cáo khoa học: Melatonin Nature’s most versatile biological signal?

Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including humans, melatonin is synthes-ized primarily in the pineal gland and is regulated by the environmental light⁄dark cycle via the suprachiasmatic nucleus. | FEBS Journal REVIEW ARTICLE Melatonin Nature s most versatile biological signal S. R. Pandi-Perumal1 V. Srinivasan2 G. J. M. Maestroni3 D. P. Cardinal 4 B. Poeggeler5 and R. Hardeland5 1 Comprehensive Center for Sleep Medicine Division of Pulmonary CriticalCare and Sleep Medicine Mount Sinai Schoolof Medicine New York USA 2 Department of Physiology Schoolof MedicalSciences University Sains Malaysia Kubang kerian Kelantan Malaysia 3 Istituto Cantonale di Patologia Locarno Switzerland 4 Department of Physiology Faculty of Medicine University of Buenos Aires Argentina 5 Institute of Zoology Anthropology and DevelopmentalBiology University of Goettingen Germany Keywords Alzheimer s disease antiapoptotic antioxidants bipolar affective disorder immune enhancing properties jet lag major depressive disorder melatonin sleep suprachiasmatic nucleus Correspondence S. R. Pandi-Perumal Comprehensive Center for Sleep Medicine Division of Pulmonary CriticalCare and Sleep Medicine Mount Sinai Schoolof Medicine Box 1232 11765th Avenue New York NY 10029 USA Fax 1 212 241 4828 Tel 1 212 241 5098 E-mail pandiperumal@ Received 25 February 2006 revised 25 April2006 accepted 15 May 2006 doi Melatonin is a ubiquitous molecule and widely distributed in nature with functional activity occurring in unicellular organisms plants fungi and animals. In most vertebrates including humans melatonin is synthesized primarily in the pineal gland and is regulated by the environmental light dark cycle via the suprachiasmatic nucleus. Pinealocytes function as neuroendocrine transducers to secrete melatonin during the dark phase of the light dark cycle and consequently melatonin is often called the hormone of darkness . Melatonin is principally secreted at night and is centrally involved in sleep regulation as well as in a number of other cyclical bodily activities. Melatonin is exclusively involved in signaling the time of day and time of year hence considered .

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