TAILIEUCHUNG - Báo cáo y học: " Previous hospital admissions and disease severity predict the use of antipsychotic combination treatment in patients with schizophrenia"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Previous hospital admissions and disease severity predict the use of antipsychotic combination treatment in patients with schizophrenia | Bolstad et al. BMC Psychiatry 2011 11 126 http 1471-244X 11 126 BMC Psychiatry RESEARCH ARTICLE Open Access Previous hospital admissions and disease severity predict the use of antipsychotic combination treatment in patients with schizophrenia Albert Bolstad1 Ole A Andreassen2 3 Jan I R0ssberg2 3 Ingrid Agartz1 2 Ingrid Melle2 3 and Lars Tanum3 4 Abstract Background Although not recommended in treatment guidelines previous studies have shown a frequent use of more than one antipsychotic agent among patients with schizophrenia. The main aims of the present study were to explore the antipsychotic treatment regimen among patients with schizophrenia in a catchment area-based sample and to investigate clinical characteristics associated with antipsychotic combination treatment. Methods The study included 329 patients diagnosed with schizophrenia using antipsychotic medication. Patients were recruited from all psychiatric hospitals in Oslo. Diagnoses were obtained by use of the Structured Clinical Interview for DSM-IV Axis I disorders SCID-I . Additionally Global Assessment of Functioning GAF Positive and Negative Syndrome Scale PANSS and number of hospitalisations and pharmacological treatment were assessed. Results Multiple hospital admissions low GAF scores and high PANSS scores were significantly associated with the prescription of combination treatment with two or more antipsychotics. The use of combination treatment increased significantly from the second hospital admission. Combination therapy was not significantly associated with age or gender. Regression models confirmed that an increasing number of hospital admission was the strongest predictor of the use of two or more antipsychotics. Conclusions Previous hospital admissions and disease severity measured by high PANSS scores and low GAF scores predict the use of antipsychotic combination treatment in patients with schizophrenia. Future studies should further explore the use of .

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