TAILIEUCHUNG - Báo cáo khoa học: Tec family kinases: regulation of FceRI-mediated mast-cell activation

Mast cells express the high-affinity receptor for IgE (FceRI) and are key players in type I hypersensitivity reactions. They are critically involved in the development of allergic rhinitis, allergic asthma and systemic anaphy-laxis, however, they also regulate normal physiological processes that link innate and adaptive immune responses. | IFEBS Journal MINIREVIEW Tec family kinases regulation of FceRI-mediated mast-cell activation Wilfried Ellmeier Anastasia Abramova and Alexandra Schebesta Division of Immunobiology Institute of Immunology Center for Pathophysiology Infectiology and Immunology MedicalUniversity of Vienna Austria Keywords cytokine production degranulation early-phase and late-phase effector functions Itk mast cell signaling Tec TLR activation type I hypersensitivity reactions tyrosine kinases Correspondence W. Ellmeier Division of Immunobiology Institute of Immunology Center for Pathophysiology Infectiology and Immunology MedicalUniversity Vienna Lazarettgasse 19 1090 Vienna Austria Fax 43 1 40160 965003 Tel 43 1 40160 65003 E-mail Received 31 August 2010 revised 3 November 2010 accepted 25 February 2011 doi Mast cells express the high-affinity receptor for IgE FceRI and are key players in type I hypersensitivity reactions. They are critically involved in the development of allergic rhinitis allergic asthma and systemic anaphylaxis however they also regulate normal physiological processes that link innate and adaptive immune responses. Thus their activation has to be tightly controlled. One group of signaling molecules that are activated upon FceRI stimulation is formed by Tec family kinases and three members of this kinase family Btk Itk and Tec are expressed in mast cells. Many studies have revealed important functions of Tec kinases in signaling pathways downstream of the antigen receptors in lymphocytes. This review summarizes the current knowledge about the function of Tec family kinases in FceRI-mediated signaling pathways in mast cell. Mast cells are crucial regulators of type I hypersensitivity reactions Mast cells are key players in type I hypersensitivity reactions and are critically involved in the development of allergic rhinitis allergic asthma and systemic anaphylaxis. Mast cells as well as basophils .

• Báo cáo khoa học
• Scientific reports
• molecular Biology
• genetics
• cell activation
• breast cancer
• medicine
• collection of scientific reports
• industry reports philosophy of history reports
• reports in literature
• a scientific b shirt
• presentation of scientific reports
• reports on literature
• philosophy statement
• documents
• studies English language and English language communication and English language commercial
• progress reports at scientific collections
• agronomic reports
• reports in physics
• biology reports
• thematic biological
• induced geometry
• mathematical topics
• quantum mechanics
• physics
• reporting mathematics
• physics reports
• livestock reports
• physical reports
• research physicist
• specializing in physics
• mathematical statements
• mathematical equations
• English pronunciation
• presentation report
• agricultural reports
• technical crops
• bio technology
• English reports
• scientific research
• presentation reports
• mathematical knowledge
• reports of mathematics
• represented
• Wilf on packing distinct
• Tur´n density
• mathematical works
• patterns in a permutation
• statements and documents scientific reports
• reports agronomy
• biotechnology
• plants Vietnam
• specialized biological
• microbiological methods
• presenting the report
• anti bacterial properties of shrimp
• energy exchange
• engineering chicken
• Path counting
• random matrix theory
• Even circuits
• prescribed clockwise parity
• Correspondence between
• algorithmic characterizations
• Finding Induced Acyclic
• Random Digraphs
• Nonexistence results
• Hadamard like matrices
• Voltage Graphs
• Group Presentations
• Cages mathematical knowledge
• Dominance Order
• Graphical Partitions
• On the functions
• values in [α(G
• Box With Translates
• Two Given Rectangular Brick
• On the q analogue
• the sum of cubes