TAILIEUCHUNG - Báo cáo khoa hoc :The AMPK⁄SNF1⁄SnRK1 fuel gauge and energy regulator: structure, function and regulation

All life forms on earth require a continuous input and monitoring of car-bon and energy supplies. The AMP-activated kinase (AMPK)⁄sucrose non-fermenting1 (SNF1)⁄Snf1-related kinase1 (SnRK1) protein kinases are evolutionarily conserved metabolic sensors found in all eukaryotic organ-isms from simple unicellular fungi (yeast SNF1) to animals (AMPK) and plants (SnRK1). | IFEBS Journal REVIEW ARTICLE The AMPK SNF1 SnRK1 fuel gauge and energy regulator structure function and regulation Ruben Ghillebert1 Erwin Swinnen1 Jing Wen1 Lies Vandesteene1 Matthew Ramon1 2 Koen Norga3 4 Filip Rolland1 and Joris Winderickx1 1 Department of Biology Laboratory for FunctionalBiology Katholieke Universiteit Leuven Heverlee Belgium 2 Department of Molecular Biology Massachusetts General Hospital Harvard University Boston MA USA 3 Laboratory for DevelopmentalGenetics Flanders Institute for Biotechnology VIB Leuven Belgium 4 Department of Woman and Child Pediatric Hematology and Oncology Katholieke Universiteit Leuven Leuven Belgium Keywords allosteric regulation AMP-activated kinase AMPK cross-species conservation energy signaling function phosphorylation Snf1-related kinase1 SnRK1 stress response structure sucrose nonfermenting1 SNF1 Correspondence J. Winderickx Laboratory for Functional Biology Kasteelpark Arenberg 31 PO Box 2433 B-3001 Heverlee Belgium Fax 32 16 321967 Tel 32 16 321516 E-mail Received 20 July 2011 accepted 22 August 2011 doi All life forms on earth require a continuous input and monitoring of carbon and energy supplies. The AMP-activated kinase AMPK sucrose non-fermenting1 SNF1 Snf1-related kinase1 SnRK1 protein kinases are evolutionarily conserved metabolic sensors found in all eukaryotic organisms from simple unicellular fungi yeast SNF1 to animals AMPK and plants SnRK1 . Activated by starvation and energy-depleting stress conditions they enable energy homeostasis and survival by up-regulating energyconserving and energy-producing catabolic processes and by limiting energy-consuming anabolic metabolism. In addition they control normal growth and development as well as metabolic homeostasis at the organismal level. As such the AMPK SNF1 SnRK1 kinases act in concert with other central signaling components to control carbohydrate uptake and metabolism fatty acid and .

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