TAILIEUCHUNG - Biochemical Pharmacology Lecture Notes

What is ‘biochemical pharmacology’? • A fancy way of saying ‘pharmacology’, and of hiding the fact that we are sneaking a subject of medical interest into the UW biochemistry curriculum. • An indication that we are not going to discuss prescriptions for your grandmother’s aching knee; we will focus on the scientific side of things but not on whether to take the small blue pill before or after the meal. What is it not? • A claim that we accurately understand the mechanism of action of each practically useful drug in biochemical terms. • A claim that enzyme mechanisms and receptor structures, or even cell biology suffice as a basis to understand drug action. | Biochemical Pharmacology Lecture Notes Michael Palmer Department of Chemistry University of Waterloo Canada Third edition January 2007 Contents About these notes . vi Chapter 1. Introduction. 1 . What are drugs . 1 . Drugs and drug target molecules . 2 . Drug molecules may or may not have physiological counterparts. 3 . Synthetic drugs may exceed the corresponding physiological agonists in selectivity . 4 . Metabolism of physiological mediators and of drugs. 5 . Strategies of drug development. 5 Chapter 2. Pharmacokinetics. 9 . Drug application and uptake. 9 . Oral drug application . 9 . Intravenous drug application . 10 . Other routes of drug applicaton . 11 . Drug distribution. 12 . Vascular permeability the blood brain barrier . 12 . Drug hydrophobicity and permeation across membranes . 12 . L-DOPA as an example of drug distribution facilitated by specific transport . 14 . The volume of distribution . 14 . Protein binding. 15 . Kinetics of drug distribution. 15 . Drug elimination Kidneys . 16 . Kidney anatomy and function . 16 . Filtration secretion reuptake. 18 . Examples. 20 . Drug elimination Metabolism . 21 . Example Metabolism of phenobarbital and of morphine . 21 . Cytochrome P450 enzymes. 22 . Overview of drug conjugation reactions . 23 . Glucuronidation. 24 . Glutathione conjugation . 24 . Acetylation . 25 . Other reactions in drug metabolism . 25 Chapter 3. Pharmacodynamics. 27 . Classes of drug receptors . 27 . Mechanisms and kinetics of drug receptor interaction. 28 . Mass action kinetics of drug-receptor binding . 28 . Reversible inhibition. 28 . Irreversible inhibition. 29 . Example Inhibition of a-adrenergic receptors by tolazoline and phenoxybenzamine . 30 . Drug dose-effect relationships in biochemical cascades . 31 . Spare receptors. 33 . Potency and efficacy . 33 . Partial agonism and

• Y học thường thức
• potassium channels
• calcium pharmacology
• Pharmacokinetics
• Drug elimination
• Glutathione conjugation
• cholinergic synapses
• In stent restenosis
• Calcium activated potassium channels
• Porcine coronary artery model
• BMC Cancer
• Triple negative breast cancer
• Breast cancer cells
• Xenograft model
• Fluorescence microscope
• BMC Pharmacology and Toxicology
• Cytostatic effect
• Sulphonylurea receptor
• ATP sensitive potassium channels
• BMC Anesthesiology
• Cardiac toxicity
• Epinephrine reversed
• High concentration bupivacaine
• Induced inhibition
• Calcium channels
• Biochemistry
• molecular Biology
• biological cells
• plant experiments
• potassium
• cytoplasm
• Lung cancer cell
• Drug resistance
• Side population
• Voltage gated potassium channel
• Combination therapy
• báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• báo cáo khao học
• báo cáo về y học
• công trình y học
• nghiên cứu y học
• trình bày báo cáo
• tài liệu báo cáo khoa học
• kiến thức y học
• Report medicine
• traditional medicine
• scientific reports
• breast cancer
• medicine
• chemical reaction
• Structural biochemistry
• bacteria
• Cerebral vasospasm
• Molecular mechanisms
• Signaling pathways
• Experimental subarachnoid hemorrhage
• Chronic cerebral vasospasm
• 5 hydroxydecanoate
• Reactive oxygen species
• Rat uterus cells
• ROS sensitive fluorescent probe
• BMC Molecular and Cell Biology
• Ischemic preconditioning
• Mitochondrial permeability transition
• Respiratory uncoupling
• BMC Genomics
• Ketamine ester analogs
• Demonstrate different pharmacological
• Both confer hypnosis