TAILIEUCHUNG - N-Terminal Pro–B-Type Natriuretic Peptide and Long-Term Mortality in Stable Coronary Heart Disease

The level of the inactive N-terminal fragment of pro–brain (B-type) natriuretic peptide (BNP) is a strong predictor of mortality among patients with acute coronary syndromes and may be a strong prognostic marker in patients with chronic coronary heart disease as well. We assessed the relationship between N-terminal pro-BNP (NT-pro-BNP) levels and long-term mortality from all causes in a large cohort of patients with stable coronary heart disease. | N-Terminal Pro-B-Type Natriuretic Peptide and Long-Term Mortality in Stable Coronary Heart Disease N-Terminal Pro-B-Type Natriuretic Peptide and Long-Term Mortality in Stable Coronary Heart Disease Charlotte Kragelund . Bjorn Gronning . Lars Kober . Per Hildebrandt . and Rolf Steffensen . abstract From the Department of Cardiology and Endocrinology Frederiksberg Hospital Fred-eriksberg . . . the Department of Cardiology Rigshospitalet Copenhagen . and the Department of Cardiology Hillerod University Hospital Copenhagen . all in Denmark. Address reprint requests to Dr. Kragelund at the Department of Cardiology and Endocrinology Frederiksberg Hospital University of Copenhagen Nordre Fasanvej 57 DK-2000 Frederiksberg Denmark or at kragelund@ . N Engl J Med 2005 352 666-75. Copyright 2005 Massachusetts Medical Society. background The level of the inactive N-terminal fragment of pro-brain B-type natriuretic peptide BNP is a strong predictor ofmortality among patients with acute coronary syndromes and may be a strong prognostic marker in patients with chronic coronary heart disease as well. We assessed the relationship between N-terminal pro-BNP NT-pro-BNP levels and long-term mortality from all causes in a large cohort ofpatients with stable coronary heart disease. methods NT-pro-BNP was measured in baseline serum samples from 1034 patients referred for angiography because ofsymptoms or signs ofcoronary heart disease. The rate ofdeath from all causes was determined after a median follow-up of nine years. results At follow-up 288 patients had died. The median NT-pro-BNP level was significantly lower among patients who survived than among those who died 120 pg per milliliter interquartile range 50 to 318 vs. 386 pg per milliliter interquartile range 146 to 897 P . Patients with NT-pro-BNP levels in the highest quartile were older had a lower left ventricular ejection fraction LVEF and a lower creatinine clearance rate .

• Y học thường thức
• medical research
• therapeutic
• N Terminal Pro–B Type
• Natriuretic Peptide
• Long Term Mortality
• pharmaceutical
• scientific reports
• treatment
• symptoms
• biochemical
• statements and documents scientific reports
• medical reports
• medical knowledge
• clinical trials
• medical management
• health care
• mmon diseases
• major medical
• Microbiology