TAILIEUCHUNG - Scanning Laser Polarimetry in Pulmonary Tuberculosis Patients on Chemotherapy

The aim of this study was to analyse the thickness of the retinal nerve fibre layer (RNFL) of pulmonary tuberculosis patients on ethambutol and isoniazid. Materials and Methods: This was a prospective cohort study where patients with newly diagnosed pulmonary tuberculosis requiring chemotherapy, including ethambutol and isoniazid, were imaged using scanning laser polarimetry. Their mean baseline RNFL thickness and various scanning laser polarimetry parameters of both eyes were measured 2 weeks after the commencement of chemotherapy. The measurements were repeated at 3 months and 6 months after treatment. The various parameters of the baseline and the follow-up measurements were compared using paired sample t-test with Bonferroni correction. Results:. | Original Article Scanning Laser Polarimetry in Pulmonary Tuberculosis Patients on Chemotherapy 1 23 3 Wilson WT 1 ang 1 2 MRcsEd MMed Ophth Jimmy SM Lai FRC0phth MMed Ophth MD Clement CY 1 ham 3FRcs Kam-Keung Chan 4FHKCp Kin-Sang Chan 4FRCp Abstract Introduction The aim of this study was to analyse the thickness of the retinal nerve fibre layer RNFL of pulmonary tuberculosis patients on ethambutol and isoniazid. Materials and Methods This was a prospective cohort study where patients with newly diagnosed pulmonary tuberculosis requiring chemotherapy including ethambutol and isoniazid were imaged using scanning laser polarimetry. Their mean baseline RNFL thickness and various scanning laser polarimetry parameters of both eyes were measured 2 weeks after the commencement of chemotherapy. The measurements were repeated at 3 months and 6 months after treatment. The various parameters ofthe baseline and the follow-up measurements were compared using paired sample f-test with Bonferroni correction. Results Twenty-four patients 16 males and 8 females mean age years were recruited. There was no statistically significant difference between the baseline and the follow-up measurements in RNFL thickness and all other scanning laser polarimetry parameters. Conclusion In this cohort of subjects there was no subclinical change in RNFL thickness detected by scanning laser polarimetry in pulmonary tuberculosis patients on chemotherapy including ethambutol and isoniazid after 6 months of treatment. Ann Acad Med Singapore 2006 35 395-9 Key words Drug toxicity Ethambutol Isoniazid Lasers Optic diseases Retina Tuberculosis Introduction Pulmonary tuberculosis is a worldwide disease. In Hong Kong there are about 7000 new cases of pulmonary tuberculosis each year and the prevalence remains high at about 110 100 2 The male elderly 60 years are at the greatest The consensus treatment regime in Hong Kong consists of a 6-month multi-drug course of chemotherapy under .

• Y học thường thức
• provides supporting
• limited ability
• Separability (RLS)
• Feature (Gene)
• Subset Selection
• Disease Gene Prioritization