TAILIEUCHUNG - Prevalence and Its Predictors of Extrapulmonary Involvement in Patients with Pulmonary Tuberculosis

Extrapulmonary organ involvement in human immunodefiaency virus (HIV)-infected patients with pulmonary tuberculosis (TB) is reported to be 26%, however, the clinical predictors of extrapulmonary involvement in pulmonary TB patients has not been reported yet. We tried to determine the clinical predictors of presence of extrapulmonary involvement in patients with pulmonary TB. Cross-sectional study was performed including all adult patients with culture-proven pulmonary TB diagnosed between January 1, 2004 and July 30, 2006, at a tertiary referral hospital in South Korea. The presence of extra-pulmonary TB involvement was diagnosed based on bacteriological, pathological, or clinical evidence. Among 320 patients with a cultureproven pulmonary TB, 40 had extrapulmonary involvement. Patients with. | J Korean Med Sci 2009 24 237-41 ISSN 1011-8934 DOI Copyright The Korean Academy of Medical Sciences Prevalence and Its Predictors of Extrapulmonary Involvement in Patients with Pulmonary Tuberculosis Extrapulmonary organ involvement in human immunodefiaency virus HlV -infect-ed patients with pulmonary tuberculosis TB is reported to be 26 however the clinical predictors of extrapulmonary involvement in pulmonary TB patients has not been reported yet. We tried to determine the clinical predictors of presence of extra-pulmonary involvement in patients with pulmonary TB. Cross-sectional study was performed including all adult patients with culture-proven pulmonary TB diagnosed between January 1 2004 and July 30 2006 at a tertiary referral hospital in South Korea. The presence of extra-pulmonary TB involvement was diagnosed based on bacteriological pathological or clinical evidence. Among 320 patients with a culture-proven pulmonary TB 40 had extrapulmonary involvement. Patients with bilateral lung involvement were more likely to have extrapulmonary involvement with an adjusted odds ratio OR of 95 confidence interval CI while patients older than 60 yr adjusted OR 95 CI patients with cavitary lesions adjusted OR 95 CI and with higher levels of serum albumin adjusted OR 95 CI had less frequent involvement. Clinicians should be aware of the possibility of extrapulmonary involvement in TB patients with bilateral lung involvement without cavity formation or lower levels of serum albumin. Key Words Tuberculosis Tuberculosis Miliary Diagnosis Min Jae Kim Hye-Ryoun Kim Seung Sik Hwang Young Whan Kim Sung Koo Han Young-Soo Shim and Jae-Joon Yim Division of Pulmonary and Critical Care Medicine Department of Internal Medicine and Lung Institute Seoul National University College of Medicine Seoul Department of Social and Preventive Medicine College of Medicine Inha University Incheon Korea Received

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