TAILIEUCHUNG - Calcium abnormalities in pulmonary tuberculosis

About a third of the world’s population is infected with Mycobacterium tuberculosis. Tuberculosis remains one of the biggest killers among infectious diseases, with up to three million people dying from tuberculosis each year (Dye 1999). Diagnosis of tuberculosis generally relies on smear microscopy and culture of the sputum. The disease typically results in progressively destructive lung lesions but may affect almost any part of the body, usually with advanced wasting and death inmore than half of cases in the absence of intervention. Despite the availability of increasingly effective treatment since the middle of the twentieth century the global burden of tuberculosis has continued to grow. This is partly because it is. | Pakistan J. Med. Res. Vol. 43 2004 Calcium abnormalities in pulmonary tuberculosis Aamir Ijaz Tariq Mehmood Waseem Saeed Ayaz Hussain Qureshi Muhammad Dilawar Masood Anwar Shujaat Hussain Farooq Ahmad Khan Iqbal Ahmad Khan Dilshad Ahmad Khan Armed Forces Institute of Pathology Army Medical College Military Hospital Rawalpindi SUMMARY Objective To study the disorders of calcium metabolism in patients with untreated pulmonary tuberculosis. Design A cross-sectional comparative study. Places and Duration of Study Department of Pathology Army Medical College and Department of Pulmonology MH Rawalpindi Department of Chemical Pathology and Endocrinology AFIP Rawalpindi from Jan 2002 to Jan 2003. Subjects Methods One hundred and fifty two patients of untreated pulmonary tuberculosis and forty four age and sex- matched disease free controls were included in the study. Blood ionized calcium Ca pH sodium Na and potassium K were analyzed by ion selective electrode method on Easylyte auto analyzer. Other related parameters were measured by colorimetric methods. Results Blood Ca levels in patients of pulmonary tuberculosis were found mean SD 014 mmol L significantly low as compared to control subjects mean SD mmol L p . Fifty two 38 subjects had hypocalcaemia while seven 5 subjects were found to be falling in hypercalcaemic range. Serum phosphate levels were also low corresponding to Ca levels control mean SD mmol L vs mmol L p . There was no statistically significant difference in other parameters . albumin urea creatinine pH Na and K levels in study subjects and controls. Conclusion Hypocalcaemia and hypphosphataemia are more prevalent in our population of untreated pulmonary tuberculosis. Key Words Pulmonary tuberculosis Hypocalcaemia Hypercalcaemia INTRODUCTION Pulmonary tuberculosis Pulm TB is still a very common cause of morbidity morbidity in our country1. Keeping in mind its high prevalence all aspects of the disease

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