TAILIEUCHUNG - Patterns of drug resistance in pulmonary tuberculosis cases in the Izmir district, Turkey

Association studies from north India probing multiple loci across the spectrum of candidate cytokine genes are scanty. The present study, therefore, was aimed to bring in focus certain unexplored polymorphisms in the context of tuberculosis susceptibility in north Indian population. The role and importance of genetic background in tuberculosis has now become univocal with ethnicity playing a crucial role. Probing new loci relating to tuberculosis susceptibility could suggest novel approach in pharmacogenomics and therapy to combat this pathogen. Also it could provide an insight into predicting individual’s genetic proneness to tuberculosis and of being future diagnostic tool for preventive therapy against tuberculosis | New Microbiologica 32 31-37 2009 Patterns of drug resistance in pulmonary tuberculosis cases in the Izmir district Turkey Dursun Tatar1 Gunes Senol2 Didem Cosar1 Rifat Ozacar1 Huseyin Halilcolar1 1Chest Diseases Clinic Izmir Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital Yenisehir Izmir Turkey 2Microbiology and Infectious Diseases Department Izmir Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital Yenisehir Izmir Turkey __ SUMMARY Antituberculosis drug resistance patterns were investigated among the new and previously treated pulmonary tuberculosis TB cases in Izmir district retrospectively. Proportions of resistance patterns were determined using a number of resistant cases using as a denominator. Resistance to at least one drug was found in 304 patients in 1023 a total of tuberculosis cases. 182 new and 82 previously treated consecutive pulmonary tuberculosis cases were investigated. Patterns were examined as single and or probable combinations of isoniazid H rifampicin R ethambutol E and streptomycin S . Single drug resistance mode mono S and HS resistance patterns were the highest proportions in comparison with other modes and patterns in both new and previously treated cases. HRS pattern showed a significant proportion and proportions of quadruple mode were higher than triple mode in previously treated cases. Proportions of patterns associated with R were detected more than expected. Surveillance of proportions of anti-TB drug resistance is important as well as surveillance of resistance rates. KEY WORDS Drug resistance Drug resistance pattern New cases Previously treated cases Tuberculosis Received March 28 2008 Accepted June 13 2008 INTRODUCTION The emergence of drug resistant strains of TB is a global threat to tuberculosis prevention and control efforts WHO 2004 . Poor or suboptimal tuberculosis control programmes

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