TAILIEUCHUNG - báo cáo hóa học:" Health-Related Quality of Life in Parkinson disease: Correlation between Health Utilities Index III and Unified Parkinson’s Disease Rating Scale (UPDRS) in U.S. male veterans"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Health-Related Quality of Life in Parkinson disease: Correlation between Health Utilities Index III and Unified Parkinson’s Disease Rating Scale (UPDRS) in . male veterans | Kleiner-Fisman et al. Health and Quality of Life Outcomes 2010 8 91 http content 8 1 91 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Health-Related Quality of Life in Parkinson disease Correlation between Health Utilities Index III and Unified Parkinson s Disease Rating Scale UPDRS in . male veterans Galit Kleiner-Fisman1 Matthew B Stern2 David N Fisman3 Abstract Objective To apply a scaled preference-based measure to the evaluation of health-related quality of life HRQoL in Parkinson s disease PD to evaluate the relationship between disease-specific rating scales and estimated HRQoL and to identify predictors of diminished HRQoL. Background Scaled preference-based measures of HRQoL utilities serve as indices of impact of disease and can be used to generate quality-adjusted estimates of survival for health-economic evaluations. Evaluation of utilities for PD and their correlation with standard rating scales have been limited. Methods Utilities were generated using the Health Utilities Index Mark III HUI-III on consecutive patients attending a PD Clinic between October 2003 and June 2006. Disease severity medical surgical subthalamic nucleus deep brain stimulation STN-DBS and demographic information were used as model covariates. Predictors of HUI-III utility scores were evaluated using the Wilxocon rank-sum test and linear regression models. Results 68 men with a diagnosis of PD and a mean age of SD were included in the data analysis. Mean HUI-III utility at first visit was SD . In multivariable models UPDRS-II score r2 P was highly predictive of HRQoL. UPDRS-III was a weaker but still significant predictor of utility scores even after adjustment for UPDRS-II P . Conclusions Poor self-care in PD reflected by worsening UPDRS-II scores is strongly correlated with low generic HRQoL. HUI-III-based health utilities display convergent validity with the UPDRS-II. These findings highlight the importance of .

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