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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Health-Related Quality of Life in Parkinson disease: Correlation between Health Utilities Index III and Unified Parkinson’s Disease Rating Scale (UPDRS) in U.S. male veterans | Kleiner-Fisman et al. Health and Quality of Life Outcomes 2010 8 91 http www.hqlo.eom content 8 1 91 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Health-Related Quality of Life in Parkinson disease Correlation between Health Utilities Index III and Unified Parkinson s Disease Rating Scale UPDRS in U.S. male veterans Galit Kleiner-Fisman1 Matthew B Stern2 David N Fisman3 Abstract Objective To apply a scaled preference-based measure to the evaluation of health-related quality of life HRQoL in Parkinson s disease PD to evaluate the relationship between disease-specific rating scales and estimated HRQoL and to identify predictors of diminished HRQoL. Background Scaled preference-based measures of HRQoL utilities serve as indices of impact of disease and can be used to generate quality-adjusted estimates of survival for health-economic evaluations. Evaluation of utilities for PD and their correlation with standard rating scales have been limited. Methods Utilities were generated using the Health Utilities Index Mark III HUI-III on consecutive patients attending a PD Clinic between October 2003 and June 2006. Disease severity medical surgical subthalamic nucleus deep brain stimulation STN-DBS and demographic information were used as model covariates. Predictors of HUI-III utility scores were evaluated using the Wilxocon rank-sum test and linear regression models. Results 68 men with a diagnosis of PD and a mean age of 74.0 SD 7.4 were included in the data analysis. Mean HUI-III utility at first visit was 0.45 SD 0.33 . In multivariable models UPDRS-II score r2 0.56 P 0.001 was highly predictive of HRQoL. UPDRS-III was a weaker but still significant predictor of utility scores even after adjustment for UPDRS-II P 0.01 . Conclusions Poor self-care in PD reflected by worsening UPDRS-II scores is strongly correlated with low generic HRQoL. HUI-III-based health utilities display convergent validity with the UPDRS-II. These findings highlight the importance of .
