TAILIEUCHUNG - báo cáo khoa học: "First-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meeting"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:First-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meeting | BioMed Central Journal of Hematology Oncology Open Access Review First-in-class first-in-human phase I results of targeted agents Highlights of the 2008 American Society of Clinical Oncology meeting Andrea Molckovsky and Lillian L Siu Address Division of Medical Oncology and Hematology Princess Margaret Hospital University of Toronto Toronto Canada Email Andrea Molckovsky - Lillian L Siu - Corresponding author Published 29 October 2008 Received 16 September 2008 Journal of Hematology Oncology 2008 1 20 doi 1756-8722-1-20 Accepted 29 October 2008 This article is available from http content 1 1 20 2008 Molckovsky and Siu licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract This review summarizes phase I trial results of 11 drugs presented at the American Society of Clinical Oncology meeting held in Chicago IL from May 30 to June 3rd 2008 BMS-663513 CT-322 CVX-045 GDC-0449 GRN163L LY2181308 PF-00562271 RAV12 RTA 402 XL765 and the survivin vaccine. Introduction This year a myriad of novel agents were introduced by way of Phase I trials at the American Society of Clinical Oncology ASCO meeting held in Chicago IL from May 30 to June 3rd 2008. With the shift of drug development from cytotoxic to targeted mechanisms of action new and exciting drug classes are being created over 10 different classes with first-in-human results were identified from this year s meeting alone. These targeted agents as compared to traditional cytotoxic therapies may have decreased toxicity and unique pharmacokinetic profiles. Furthermore armed with pharmacodynamic assays that measure successful inhibition of designated targets these phase I trial results suggest potential .

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