TAILIEUCHUNG - báo cáo khoa học: "Sentinel lymph node biopsy using dye alone method is reliable and accurate even after neo-adjuvant chemotherapy in locally advanced breast cancer - a prospective study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Sentinel lymph node biopsy using dye alone method is reliable and accurate even after neo-adjuvant chemotherapy in locally advanced breast cancer - a prospective study | Chintamani et al. World Journal of Surgical Oncology 2011 9 19 http content 9 1 19 5 2 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Sentinel lymph node biopsy using dye alone method is reliable and accurate even after neo-adjuvant chemotherapy in locally advanced breast cancer - a prospective study Chintamani 1 Megha Tandon 1 Ashwani Mishra Usha Agarwal Sunita Saxena Abstract Background Sentinel lymph node biopsy SLNB is now considered a standard of care in early breast cancers with NO axillae however its role in locally advanced breast cancer LABC after neo-adjuvant chemotherapy NACT is still being debated. The present study assessed the feasibility efficacy and accuracy of sentinel lymph node biopsy SLNB using dye alone methylene blue method in patients with LABC following NACT. Materials and methods Thirty biopsy proven cases of LABC that had received three cycles of neo-adjuvant chemotherapy cyclophosphamide adriamycin 5-fluorouracil were subjected to SLNB using methylene blue dye followed by complete axillary lymph node dissection levels I-III . The sentinel node s was were and the axilla were individually assessed histologically. The SLN accuracy parameters were calculated employing standard definitions. The SLN identification rate in the present study was 100 . The sensitivity of SLNB was while the accuracy was which were comparable with other studies done using dual lymphatic mapping method. The SLN was found at level I in all cases and no untoward reaction to methylene blue dye was observed. Conclusions This study confirms that SLNB using methylene blue dye as a sole mapping agent is reasonably safe and almost as accurate as dual agent mapping method. It is likely that in the near future SLNB may become the standard of care and provide a less morbid alternative to routine axillary lymph node dissection even in patients with LABC that have received NACT. Introduction Breast cancer is the most common site

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