TAILIEUCHUNG - Icodextrin reduces adhesion formation following gynecological surgery in rabbits

Drinking and driving: It doesn’t take much alcohol to impair a person’s ability to drive. The chances of being killed in a single-vehicle crash are increased at a blood alcohol level that a 140-lb. woman would reach after having one drink on an empty stomach. Medication interactions: Alcohol can interact with a wide variety of medicines, both prescription and over-the-counter. Alcohol can reduce the effectiveness of some medications, and it can combine with other medications to cause or increase side effects. Alcohol can interact with medicines used to treat conditions as varied as heart and blood vessel disease, digestive problems,. | Iranian Journal of Reproductive Medicine . . pp 187-192 Summer 2011 Icodextrin reduces adhesion formation following gynecological surgery in rabbits Behnaz Khani1 . Nahid Bahrami . Ferdous Mehrabian2 . Hormoz Naderi Naeni3 . 1 Department of Obstetrics and Gynecology Shahid Beheshti Hospital Isfahan University of Medical Sciences Isfahan Iran. 2 Department of Obstetrics and Gynecology Alzahra Hospital Isfahan University of Medical Sciences Isfahan Iran. 3 Sepahan Hospital Isfahan Iran. Received 8 May 2010 accepted 11 January 2011 Abstract Background Adhesion is a common complication of gynecology surgery so different barrier agents and solutions have been used during these operations to separate and protect tissues from adhesion after surgery. Adept is one of these solutions that have been postulated to reduce the chance of adhesion following gynecolgy surgery. Objective To evaluate the effect of 4 icodextrin in reducing adhesion formation in comparing with sterile water and human amniotic fluid in rabbits. Materials and Methods In this prospective experimental study 30 white Newzealand female rabbits were selected and randomized in to three treatment groups. The rabbits were anesthetized and an abdominal incison was made uterine horns were abrated with gauze until bleeding occurred. Before closing the abdomen the traumatized area was irrigated either by 30cc of sterile water 30cc of 4 Adept or 30cc of human amniotic fluid. The solutions were labeled only as solutions A steriel water B icodextrin or C human amniotic fluid . On the seventh day after surgery second laparotomy was performed to determine and compare adhesion formation in rabbits. Results There was significant difference between mean score of adhesions in 4 icodextrin group in comparison to sterile water group and amniotic fluid group . But the difference between mean score of adhesions in amniotic fluid group in comparison to sterile water group was not .

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