TAILIEUCHUNG - Báo cáo khoa học: Membrane compartments and purinergic signalling: the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling

Purinergic signalling is implicated in virtually any cellular and physiological function. These functions are mediated through the activation of different receptor subfamilies, among which P2X receptors (P2XRs) are ligand-gated ion channels that respond mostly to ATP. | MINIREVIEW Membrane compartments and purinergic signalling the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling Mikel Garcia-Marcos1 Jean-Paul Dehaye2 and Aida Marino3 1 Department of Cellular and Molecular Medicine University of California San Diego La Jolla CA USA 2 Laboratoire de Biochimie et de Biologie Cellulaire Institut de Pharmacie . 205 3 Universite libre de Bruxelles Belgium 3 Departamento de Bioquimica y Biologia Molecular Universidad del Pais Vasco Bilbao Spain Keywords caveolae compartmentalization detergentresistant membrances ectonucleotidases lipid rafts membrane fractionation microdomains P2X purinergic receptors purinoceptors Correspondence M. Garcia-Marcos 9500 Gilman Dr. Mailcode 0651 La Jolla CA 92093-0651 USA Fax 1 858 534 8649 Tel 1 858 534 7713 E-mail mgarciamarcos@ Received 15 July 2008 accepted 29 September 2008 doi Purinergic signalling is implicated in virtually any cellular and physiological function. These functions are mediated through the activation of different receptor subfamilies among which P2X receptors P2XRs are ligand-gated ion channels that respond mostly to ATP. In addition to forming a nonse-lective cation channel these receptors engage with a complex network of signalling pathways including protein kinase cascades lipid signal mediators and proteases. It is poorly understood how P2XR stimulation couples to such a variety of intracellular pathways and how the outcome from this complex signalling network is tuned. In this context segregation of receptors and other signalling components at the plasma membrane is an attractive explanation. Lipid rafts are microdomains of biological membranes with unique physicochemical properties that make them segregate from the bulk of the membrane provoking the differential partition of receptors and signalling molecules among different domains of the plasma membrane. Here we give an overview of the properties of

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