TAILIEUCHUNG - Báo cáo khoa học: Cell-penetrating peptide-conjugated XIAP-inhibitory cyclic hexapeptides enter into Jurkat cells and inhibit cell proliferation

X-Linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis protein family that is overexpressed in human can-cers. There is great interest in the development of XIAP inhibitors, which are predicted to promote apoptosis in cancer cells and thus have therapeutic potential. | ỊFEBS Journal Cell-penetrating peptide-conjugated XIAP-inhibitory cyclic hexapeptides enter into Jurkat cells and inhibit cell proliferation Yusuke Sasaki1 Motoko Minamizawa1 Akihiro Ambo1 Shigeki Sugawara2 Yukiko Ogawa and Kazuo Nitta2 1 Department of Biochemistry Tohoku PharmaceuticalUniversity Sendai Japan 2 Institute of Molecular Biomembrane and Glycobiology Tohoku PharmaceuticalUniversity Sendai Japan Keywords antiproliferative activity apoptosis cell-penetrating peptide Jurkat cell XIAP inhibitory cyclic hexapeptide Correspondence Y. Sasaki Tohoku Pharmaceutical University 4-4-1 Komatsushima Aoba-ku Sendai 981 8558 Japan Fax 81 22 275 2013 Tel 81 22 727 0213 E-mail ysasaki@ Present address Department of Microbiology Nagasaki InternationalUniversity Sasebo Japan Received 24 August 2008 revised 29 September 2008 accepted 6 October 2008 doi X-Linked inhibitor of apoptosis protein XIAP is a member of the inhibitor of apoptosis protein family that is overexpressed in human cancers. There is great interest in the development of XIAP inhibitors which are predicted to promote apoptosis in cancer cells and thus have therapeutic potential. A cyclic hexapeptide CH CPFKQC which is one of the consensus motifs that can bind to the baculovirus IAP repeat 2 domain of XIAP has been identified using phage-displayed combinatorial chemistry techniques Tamm I Trepel M Cardo-Vila M Sun Y Welsh K Cabezas E Swatterthwait A Arap W Reed JC Pasqualini R 2003 Peptides targeting caspase inhibitors. J Biol Chem 278 14401-14405 . In this study we designed and synthesized covalently linked conjugates of CHs cyclo Cys-Pro-Xaa-Lys-Gln-Glu -CO- -NH2 Xaa various amino acids cyclization via a peptide bond between the N-terminal amino group of Cys1 and the side-chain carboxylic acid of Glu6 and a cell-penetrating peptide CPP Ac-Cys-Trp- Arg 8-Lys-NH2. CH-CPP conjugates CHCPPs with aromatic and hydrophobic Xaa residues such as Phe CHCPP 1 2 .

• Báo cáo khoa học
• scientific reports
• medical reports
• health education
• genetics
• Structural biochemistry
• Structural Biology
• collection of scientific reports
• industry reports philosophy of history reports
• reports in literature
• a scientific b shirt
• presentation of scientific reports
• reports on literature
• philosophy statement
• documents
• studies English language and English language communication and English language commercial
• progress reports at scientific collections
• agronomic reports
• reports in physics
• biology reports
• thematic biological
• induced geometry
• mathematical topics
• quantum mechanics
• physics
• reporting mathematics
• physics reports
• livestock reports
• physical reports
• research physicist
• specializing in physics
• mathematical statements
• mathematical equations
• English pronunciation
• presentation report
• agricultural reports
• technical crops
• bio technology
• English reports
• scientific research
• presentation reports
• mathematical knowledge
• reports of mathematics
• represented
• Wilf on packing distinct
• Tur´n density
• mathematical works
• patterns in a permutation
• statements and documents scientific reports
• reports agronomy
• biotechnology
• plants Vietnam
• specialized biological
• microbiological methods
• presenting the report
• anti bacterial properties of shrimp
• energy exchange
• engineering chicken
• Path counting
• random matrix theory
• Even circuits
• prescribed clockwise parity
• Correspondence between
• algorithmic characterizations
• Finding Induced Acyclic
• Random Digraphs
• Nonexistence results
• Hadamard like matrices
• Voltage Graphs
• Group Presentations
• Cages mathematical knowledge
• Dominance Order
• Graphical Partitions
• On the functions
• values in [α(G
• Box With Translates
• Two Given Rectangular Brick
• On the q analogue
• the sum of cubes