TAILIEUCHUNG - A Novel Endothelial L-Selectin Ligand Activity in Lymph Node Medulla That Is Regulated by (1,3)-Fucosyltransferase-IV

Of the 48 species from 46 genera and 40 families (Table 1) discussed in the present study, indigenous uses of about 70% species resembled to the earlier ethnomedicinal reports. The indigenous uses of about 50% species had affinity to the Ayurveda, and about 40% species were found to have efficacy in pharmacology. Fabaceae, Mora- ceae and Rosaceae were represented by the greatest num- ber of species (3 each), followed by Euphorbiaceae and Lamiaceae (2 each) for herbal medicine in study area. A total of 30 ailments were reported in the present study, and among these inflammation, cuts & wounds, diarrhea & dysentery and fever were considered as common, and the maximum number. | A Novel Endothelial L-Selectin Ligand Activity in Lymph Node Medulla That Is Regulated by a 1 3 -Fucosyltransferase-IV Christine M Rini 1 Guiying Cheng 1 Colleen Schweitzer 1 Lois L. Cavanagh 1 2 Roger T. Palframan 1 2 Thorsten R. Mempel 1 Richard A. Warnock 1 3 John B. Lowe 4 Elizabeth J. Quackenbush 1 5 and Ulrich H. von Andrian1 2 1CBR Institute for Biomedical Research and Department of Pathology Harvard Medical School Boston MA 02115 Laboratory of Immunology and Vascular Biology Department of Pathology Stanford University Medical School Stanford CA 94305 4Howard Hughes Medical Institute and Department of Pathology University of Michigan Medical School Ann Arbor MI 48109 5Merck Research Laboratories Division of Pharmacology Merck and Company Rahway NJ 07065 The Journal of Experimental Medicine Abstract Lymphocytes home to peripheral lymph nodes PLNs via high endothelial venules HEVs in the subcortex and incrementally larger collecting venules in the medulla. HEVs express ligands for L-selectin which mediates lymphocyte rolling. L-selectin counterreceptors in HEVs are recognized by mAb MECA-79 a surrogate marker for molecularly heterogeneous glycans termed peripheral node addressin. By contrast we find that medullary venules express L-selectin ligands not recognized by MECA-79. Both L-selectin ligands must be fucosylated by a 1 3 -fucosyltransferase FucT -IV or FucT-VII as rolling is absent in l ud -IV VII mice. Intravital microscopy experiments revealed that MECA-79 reactive ligands depend primarily on FucT-VII whereas MECA-79-independent medullary L-selectin ligands are regulated by FucT-IV. Expression levels of both enzymes paralleled these anatomical distinctions. The relative mRNA level of FucT-IV was higher in medullary venules than in HEVs whereas FucT-VII was most prominent in HEVs and weak in medullary venules. Thus two distinct L-selectin ligands are segmentally confined to contiguous microvascular domains in PLNs. Although MECA-79 reactive species .

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