TAILIEUCHUNG - Association between transforming growth factor b1 polymorphisms and atrial fibrillation in essential hypertensive subjects

The association of TGF b1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The polymorphisms of +869 T ® C at codon 10 and + 915 G ® C at codon 25, were genotyped. The clinical characteristics including serum TGF b1 levels were detected. Results: The GG genotypes of TGF b1 +915 G ® C at codon 25 were more prevalent in subjects from EH+AF+ group than those from EH+AF- group (P = ). The subjects with GG genotype from EH+AF+ group had the. | Wang et al. Journal of Biomedical Science 2010 17 23 http content 17 1 23 The cost of publication in Journal of Biomedical Science Is borne by the National Science Council Taiwan JOURNAL OF BIOMEDICAL SCIENCE RESEARCH Open Access Association between transforming growth factor pi polymorphisms and atrial fibrillation in essential hypertensive subjects Yongzheng Wang1 Xuwei Hou2 Yuliang Li1 Abstract Background The association of TGF pi polymorphisms and atrial fibrillation AF in essential hypertensive EH subjects remains unknown. Methods EH subjects with AF EH AF and sinus rhythm EH AF- were enrolled. The polymorphisms of 869 T C at codon 10 and 915 G C at codon 25 were genotyped. The clinical characteristics including serum TGF p1 levels were detected. Results The GG genotypes of TGF p1 915 G C at codon 25 were more prevalent in subjects from EH AF group than those from EH AF- group P . The subjects with GG genotype from EH AF group had the highest mean serum TGF p1 level which was significantly higher than that of GG genotype subjects from EH AF-group ng dl ng dl P . Multiple analyses revealed that the TGF p1 GG genotype of 915 G C at codon 25 presented a times higher risk in developing AF in the multivariate model after adjusting for age and gender. Conclusion The polymorphisms of TGF p1 915 G C at codon 25 were associated with occurrence of AF and serum TGF p1 level in EH subjects. Background Atrial fibrillation AF is a common and clinically important arrhythmia in practice which represents a major public health problem. AF induces hemodynamic imp airment and thromboembolic events resulting in significant morbidity mortality and cost 1 2 . A number of factors . age coronary artery disease myocardial infarction heart failure valvular heart disease contribute to the occurrence and development of AF 3 4 . In addition population based studies revealed that hypertension is an independent risk factor .

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