TAILIEUCHUNG - Biomedical Engineering From Theory to Applications Part 3

Tham khảo tài liệu 'biomedical engineering from theory to applications part 3', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 50 Biomedical Engineering - From Theory to Applications feedback regulation of thyroid hormones. It was a representative example of pathway A typical of classic physiological feedback with a controller -the thyroid gland- embedded in the human body. One of the physicians proposed a different challenging test to students how to model another pathology with growing interest in endocrinology . the obesity This challenge was very complex and unsolved from a mathematical viewpoint. It was a classical example of Babel tower because what physicians expected from us was impossible to be fulfilled in a deterministic framework similar to the approach leading to the thyroid model. First we tried to consider differential equations for modelling dynamics of hormones like leptin and ghrelin playing an important role in controlling our weight but the results obtained were too qualitative simple and poor to mimic the multi-factorial aspects of obesity. It seemed to be a failed attempt because it produced a useless model. Hence we decided to change our approach to the challenge if a deterministic model was inadequate a data-driven black box model could be an alternative solution and we decided to follow pathway B. We came to the conclusion that the first and reachable step for coping with obesity was to build an interactive user-friendly and graphically oriented toolbox for classifying obese patients. Therefore a SW tool named Obefix was developed for helping physicians in the classification of obese patients from physiological and psychological data. Obefix program Landi et al. 2007 was designed in order to produce an easy-to-use software tool for capturing all essential information on the patients using a reduced data set solving the problem related to the high data dimensionality. Fig. 3. Obefix window for a classification of obese patients the interface Physiological Cybernetics An Old-Novel Approach for Students in Biomedical Systems 51 An interesting outcome was that this

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