TAILIEUCHUNG - Chapter 108. Hematopoietic Cell Transplantation (Part 4)

Complications Following Hematopoietic Cell Transplant Early Direct Chemoradiotoxicities The transplant preparative regimens commonly used cause a spectrum of acute toxicities that vary according to the specific regimen but frequently result in nausea, vomiting, and mild skin erythema (Fig. 108-1). Regimens that include high-dose cyclophosphamide can result in hemorrhagic cystitis, which can usually be prevented by bladder irrigation or with the sulfhydryl compound mercaptoethanesulfonate (MESNA); rarely, acute hemorrhagic carditis is seen. Most preparative regimens will result in oral mucositis, which typically develops 5–7 days posttransplant and often requires narcotic analgesia. Use of a patient- controlled analgesic pump provides the greatest patient satisfaction and. | Chapter 108. Hematopoietic Cell Transplantation Part 4 Complications Following Hematopoietic Cell Transplant Early Direct Chemoradiotoxicities The transplant preparative regimens commonly used cause a spectrum of acute toxicities that vary according to the specific regimen but frequently result in nausea vomiting and mild skin erythema Fig. 108-1 . Regimens that include high-dose cyclophosphamide can result in hemorrhagic cystitis which can usually be prevented by bladder irrigation or with the sulfhydryl compound mercaptoethanesulfonate MESNA rarely acute hemorrhagic carditis is seen. Most preparative regimens will result in oral mucositis which typically develops 5-7 days posttransplant and often requires narcotic analgesia. Use of a patient- controlled analgesic pump provides the greatest patient satisfaction and results in a lower cumulative dose of narcotic. Patients begin losing their hair 5-6 days posttransplant and by 1 week are usually profoundly pancytopenic. Figure 108-1 Pancyl oponia Niriilinpirya I liriXntiXyrturtKva Regimen-relared losicilies Muesli VDD idtjpathic pHiiniiKCB Gifln-ws-host Infections Badenal Fungal Viral Acut GVHC Chronic GVHD Gram positive Gram bndana CantHa Aspergilhus HSV CMV and adenovirus DeyO Day Day 60 GmyW Oay taj Day 3W Sours i Fkua AS. K- fp r E L. B unwtld I. Hauntr SL. J m ii3n JCr Lok-aIeo Ji jHtarttan i AijAe. 2 4 rft iM 17th Ed iien www. timAdi . . a i . i Jf j JWj Hf f i Copyright h Th Mrffriw-HlU e mpini fa inc 11 nghtj r f rv d Major syndromes complicating marrow transplantation. VOD venoocclusive disease GVHD graft-versus-host disease HSV herpes simplex virus CMV cytomegalovirus VZV varicella-zoster virus. The size of the shaded area roughly reflects the risk of the complication. Approximately 10 of patients will develop venoocclusive disease of the liver a syndrome resulting from direct cytotoxic injury to hepatic-venular and sinusoidal endothelium with subsequent .

• Y học thường thức
• Hematopoietic Cell Transplantation
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu học ngành y
• Harrisons Internal Medicine
• BMC Cancer
• Cumulative incidence rates
• Transplantation related mortality
• Risk factor
• Hematopoietic stem cell transplantation
• Acute leukemia
• Intestinal mucositis
• Diamine oxidase
• Circulating citrulline
• Pre HSCT factors
• Graft versus host disease
• Post traumatic stress disorder
• Hospital Anxiety and Depression Scale
• Acute lymphoblastic leukemia
• Tyrosine kinase inhibitor
• Chronic myeloid leukemia
• Kinase inhibitors
• B thalassemia major
• Fanconi’s anemia
• Immunodeficiency diseases
• Inherited metabolic disorders
• BMC Pediatrics
• Inhibin B
• Anti Müllerian hormone
• Luteinizing hormone
• Pediatric intensive care unit
• Possible predictive factors
• Pediatric critical illness score
• Peptides regulating gastrointestinal tract functions
• Gastrointestinal tract complications
• Acute graft versus
• Donor leukemia
• Whole exome sequencing
• Skin cancer
• Skin self examination
• Early detection
• Patient activation
• Veno occlusive disease
• Cytokine serum
• Interleukin 8
• Acute myeloid leukemia
• Allogeneic hematopoietic stem cell transplantation
• Wilms’ tumor gene 1
• Prognostic role
• BMC Pulmonary Medicine
• Late onset noninfectious pulmonary complications
• Pleuroparenchymal fibroelastosis
• Idiopathic pneumonia syndrome
• Childhood acute myeloid leukemia
• Allogeneic hematopoietic stem cell transplantation
• Pediatric acute myeloid leukemia
• Overall survival
• Area under the concentration time curve
• Meta analysis
• ß blocker
• Repurposed drugs
• Multiple myeloma