TAILIEUCHUNG - Chapter 108. Hematopoietic Cell Transplantation (Part 1)

Harrison's Internal Medicine Chapter Transplantation 108. Hematopoietic Cell Hematopoietic Cell Transplantation: Introduction Bone marrow transplantation was the original term used to describe the collection and transplantation of hematopoietic stem cells, but with the demonstration that the peripheral blood and umbilical cord blood are also useful sources of stem cells, hematopoietic cell transplantation has become the preferred generic term for this process. The procedure is usually carried out for one of two purposes: (1) to replace an abnormal but nonmalignant lymphohematopoietic system with one from a normal donor, or (2) to treat malignancy by allowing the administration of higher doses of myelosuppressive therapy than. | Chapter 108. Hematopoietic Cell Transplantation Part 1 Harrison s Internal Medicine Chapter 108. Hematopoietic Cell Transplantation Hematopoietic Cell Transplantation Introduction Bone marrow transplantation was the original term used to describe the collection and transplantation of hematopoietic stem cells but with the demonstration that the peripheral blood and umbilical cord blood are also useful sources of stem cells hematopoietic cell transplantation has become the preferred generic term for this process. The procedure is usually carried out for one of two purposes 1 to replace an abnormal but nonmalignant lymphohematopoietic system with one from a normal donor or 2 to treat malignancy by allowing the administration of higher doses of myelosuppressive therapy than would otherwise be possible. The use of hematopoietic cell transplantation has been increasing both because of its efficacy in selected diseases and because of increasing availability of donors. The International Bone Marrow Transplant Registry http estimates that about 50 000 transplants are performed each year. The Hematopoietic Stem Cell Several features of the hematopoietic stem cell make transplantation clinically feasible including its remarkable regenerative capacity its ability to home to the marrow space following intravenous injection and the ability of the stem cell to be cryopreserved. Transplantation of a single stem cell can replace the entire lymphohematopoietic system of an adult mouse. In humans transplantation of a few percent of a donor s bone marrow volume regularly results in complete and sustained replacement of the recipient s entire lymphohematopoietic system including all red cells granulocytes B and T lymphocytes and platelets as well as cells comprising the fixed macrophage population including Kupffer cells of the liver pulmonary alveolar macrophages osteoclasts Langerhans cells of the skin and brain microglial cells. The ability of the hematopoietic stem .

• Y học thường thức
• Hematopoietic Cell Transplantation
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu học ngành y
• Harrisons Internal Medicine
• BMC Cancer
• Cumulative incidence rates
• Transplantation related mortality
• Risk factor
• Hematopoietic stem cell transplantation
• Acute leukemia
• Intestinal mucositis
• Diamine oxidase
• Circulating citrulline
• Pre HSCT factors
• Graft versus host disease
• Post traumatic stress disorder
• Hospital Anxiety and Depression Scale
• Acute lymphoblastic leukemia
• Tyrosine kinase inhibitor
• Chronic myeloid leukemia
• Kinase inhibitors
• B thalassemia major
• Fanconi’s anemia
• Immunodeficiency diseases
• Inherited metabolic disorders
• BMC Pediatrics
• Inhibin B
• Anti Müllerian hormone
• Luteinizing hormone
• Pediatric intensive care unit
• Possible predictive factors
• Pediatric critical illness score
• Peptides regulating gastrointestinal tract functions
• Gastrointestinal tract complications
• Acute graft versus
• Donor leukemia
• Whole exome sequencing
• Skin cancer
• Skin self examination
• Early detection
• Patient activation
• Veno occlusive disease
• Cytokine serum
• Interleukin 8
• Acute myeloid leukemia
• Allogeneic hematopoietic stem cell transplantation
• Wilms’ tumor gene 1
• Prognostic role
• BMC Pulmonary Medicine
• Late onset noninfectious pulmonary complications
• Pleuroparenchymal fibroelastosis
• Idiopathic pneumonia syndrome
• Childhood acute myeloid leukemia
• Allogeneic hematopoietic stem cell transplantation
• Pediatric acute myeloid leukemia
• Overall survival
• Area under the concentration time curve
• Meta analysis
• ß blocker
• Repurposed drugs
• Multiple myeloma