TAILIEUCHUNG - Coffee consumption modifies risk of estrogen- receptor negative breast cancer

Addressing the health needs of women living with HIV/AIDS presents special challenges, including that of screening for cervical cancer. These women are at increased risk of HPV infection, and thus, of developing cervical cancer, 26, 27 an AIDS-defining condition. 28 While the current document cannot review this topic in detail, studies are available with information on whether there is a need for specific screening guidelines for HIV- positive women. 29, 27 Some studies have investigated the time to HPV infection after incident HIV infection30 and others have begun to investigate the effect of treatment of CIN on subsequent risk of acquiring HIV. 12 Because women. | Li et al. Breast Cancer Research 2011 13 R49 http content 13 3 R49 Breast Cancer RESEARCH RESEARCH ARTICLE Open Access Coffee consumption modifies risk of estrogen-receptor negative breast cancer 3 3 4 2 1 Jingmei Li 1 Petra Seibold Jenny Chang-Claude Dieter Flesch-Janys Jianjun Liu Kamila Czene Keith Humphreys1 and Per Hall1 Abstract Introduction Breast cancer is a complex disease and may be sub-divided into hormone-responsive estrogen receptor ER positive and non-hormone-responsive subtypes ER-negative . Some evidence suggests that heterogeneity exists in the associations between coffee consumption and breast cancer risk according to different estrogen receptor subtypes. We assessed the association between coffee consumption and postmenopausal breast cancer risk in a large population-based study 2 818 cases and 3 111 controls overall and stratified by ER tumour subtypes. Methods Odds ratios OR and corresponding 95 confidence intervals CI were estimated using the multivariate logistic regression models fitted to examine breast cancer risk in a stratified case-control analysis. Heterogeneity among ER subtypes was evaluated in a case-only analysis by fitting binary logistic regression models treating ER status as a dependent variable with coffee consumption included as a covariate. Results In the Swedish study coffee consumption was associated with a modest decrease in overall breast cancer risk in the age-adjusted model OR 5 cups day compared to OR 1 cup day 95 CI P trend . In the stratified case-control analyses a significant reduction in the risk of ER-negative breast cancer was observed in heavy coffee drinkers OR 5 cups day compared to OR 1 cup day 95 CI P trend in a multivariate-adjusted model. The breast cancer risk reduction associated with higher coffee consumption was significantly higher for ER-negative compared to ER-positive tumours P heterogeneity age-adjusted . Conclusions

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