TAILIEUCHUNG - Báo cáo khoa học: " Pharmacoknetic study of diclofenac and its interaction with enrofloxacin in buffalo calves"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Pharmacoknetic study of diclofenac and its interaction with enrofloxacin in buffalo calves | J. Vet. Sei. 2003 4 2 155-159 Veterinary Science Pharmacoknetic Study of Diclofenac and Its Interaction with Enrofloxacin in Buffalo Calves Nitesh Kumar Shankar Dayal Singh and Chellappa Jayachandran Department of Pharmacology and Toxicology Bihar Veterinary College Patna Bihar 800014 India Received January 2 2003 Accepted June 7 2003 Abstract A comparative pharmacokinetic study of diclofenac 1 mg kg . when given alone or in combination with enrofloxacin 4 mg kg . in five buffalo calves was carried out by using HPLC. The study revealed that the plasma concentrations of diclofenac were significantly lower p in combined administration of diclofenac with enrofloxacin to 3 h whereas significantly higher p levels of plasma drug concentrations were observed in later period 8 to 24 h . In urine significantly lower p drug concentrations of diclofenac were observed from to h whereas significantly higher p urine drug concentrations were observed in later period 4 to 48 h when diclofenac was given in combination with enrofloxacin as compared to when diclofenac was given alone. Various kinetic parameters like A Cp and B were significantly lower p whereas ti 2 B AUMC MRT and various volume of distribution Vdc VdB Vdarea and Vdss were significantly higher in combined administration of diclofenac with enro-floxacin as compared to when diclofenac was given alone p . Key Words kinetics diclofenac interaction enrofloxacin buffalo calves Introduction Non-steroidal anti-inflammatory drugs NSAIDs are usually combined with antimicrobial agents to treat various systemic infections accompanied by fever and other inflammatory conditions. Diclofenac is a potent NSAID with good analgesic antipyretic and uricosuric properties. It produces its effects by irreversibly inhibiting the cyclooxygenase pathway of prostaglandin synthesis which is the most common mediator of pain inflammation and pyrexia. It is used in Corresponding author c. .

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