TAILIEUCHUNG - Báo cáo khoa học: " Effective methods for the production of immunoglobulin Y using immunogens of Bordetella bronchiseptica , Pasteurella multocida and Actinobacillus pleuropneumoniae"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Effective methods for the production of immunoglobulin Y using immunogens of Bordetella bronchiseptica , Pasteurella multocida and Actinobacillus pleuropneumoniae | J. Vet. Sci. 2002 3 1 47-57 JOURNAL OF Veterinary Science Effective methods for the production of immunoglobulin Y using immunogens of Bordetella bronchiseptica Pasteurella multocida and Actinobacillus pleuropneumoniae Na Ri Shin In Soo Choi Jong Man Kim1 Won Hur2and Han Sang Yoo Department of Infectious Diseases College of Veterinary Medicine and School of Agricultural Biotechnology Seoul National University Suwon 441-744 Division of Bacteriology and Immunology National Veterinary Research and Quarantine Service An Yang 430-016 2Daesung Microbiological Co. Ltd. Ewang 437-040 Korea ABSTRACT Swine respiratory diseases induce severe economic losses in the swine industry worldwide. Several methods have been developed and applied to control these diseases. However there are still problems of disease control in the swine industry. Recently egg yolk antibodies have been found to offer several advantages for disease control in animals and humans. In a previous study 24 antibodies to several causative pathogens of swine respiratory diseases were developed. However several problems remained especially in terms of reduced laying rates. Therefore experimental vaccines were reformulated with various bacterial antigens of the swine respiratory diseases. After immunizing hens with the antigens antibody profiles and other effects including laying rates were investigated and compared to those of the previous study. Profiles of antibody titers were very similar with those of the previous study. However side effects such as depression weakness reduction of laying rates and mortality were dramatically lowered and laying rates were increased in hens injected with certain experimental vaccines. In particular laying rates of hens injected with vaccines against atrophic rhinitis were increased up to 84 by injecting a vaccine composed of only the DNTs of B. bron-chiseptica and P. multocida D 4. Efficacies of the vaccines against swine pneumonic pasteurellosis and pleuropneumonia were very

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