TAILIEUCHUNG - Báo cáo khoa học: A study of microRNAs in silico and in vivo: emerging regulators of embryonic stem cells

MicroRNAs (miRNAs) are noncoding regulatory RNAs that function via the degradation of target mRNAs and inhibition of translation. They are found widely in higher eukaryotic organisms, and in several species that have been closely examined, hundreds of miRNAs have thus far been discovered with mechanistically conserved, yet functionally diverse, roles necessary for the proper development, homeostasis and metabolism of the organisms. | ễFEBS Journal MINIREVIEW A study of microRNAs in silico and in vivo emerging regulators of embryonic stem cells Kye-Seong Kim1 Jong S. Kim1 Man R. Lee1 Hoe S. Jeong1 and Jaesang Kim2 1 Department of Anatomy and CellBiology and Department of BiomedicalScience Hanyang University College of Medicine Korea 2 Division of Life and PharmaceuticalSciences Ewha Womans University Seoul Korea Keywords cell fate control differentiation embryonal carcinoma cell embryonic stem cell miRNA pluripotency stemness regulation Correspondence . Kim Department of Anatomy and Cell Biology and Department of Biomedical Science Hanyang University College of Medicine 17 Haengdang-dong Seongdong-gu Seoul 133-791 Korea Fax 82 2 2281 7841 Tel 82 2 2220 0607 E-mail ks66kim@ Received 1 September 2008 revised 21 December 2008 accepted 14 January 2009 doi MicroRNAs miRNAs are noncoding regulatory RNAs that function via the degradation of target mRNAs and inhibition of translation. They are found widely in higher eukaryotic organisms and in several species that have been closely examined hundreds of miRNAs have thus far been discovered with mechanistically conserved yet functionally diverse roles necessary for the proper development homeostasis and metabolism of the organisms. Mammalian cells produce miRNAs in a cell-type-specific manner and utilize them to regulate unique subsets of genes expressed in the host cells. This rule also appears to apply to the pluripotent embryonic stem cells according to several recent studies that reported identification of specifically expressed miRNAs. Intense interest in these miRNAs stems in part from the possibility that they are one of the determinants of the salient characteristics of these cells self-renewal capacity and pluripotency. As functional data supporting this hypothesis are beginning to accumulate it can be envisioned that miRNAs may be useful as molecular tools for manipulating ESCs. This review .

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