TAILIEUCHUNG - Obstetrics and Gynecology Clinics of North America

The term thrombophilia describes a range of conditions in which there is an increased tendency, frequently recurrent, for thrombus formation in the venous as well as in the arterial vascular systems. Thrombophilia is caused by inherited or acquired conditions and may cause symptoms related to the place in which the thrombosis occurred, the extent of thrombosis, and whether embolization occurred in other organs. | ELSEVIER VUADtRt OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA ELSEVIER SAUNDERS Obstet Gynecol Clin N Am 33 2006 xiii-xiv OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA Foreword Thrombophilia and Women s Health William F. Rayburn MD Consulting Editor Several important regulatory proteins act as inhibitors to the coagulation cascade. Genetic or acquired deficiencies of these inhibitory proteins are referred to collectively as thrombophilias which can lead to hypercoagulability conditions and to recurrent venous thromboembolisms. Information concerning thrombophilias is accruing rapidly causing certain confusions in diagnosis and management. This issue of the Obstetrics and Gynecology Clinics of North America guest edited by Dr. Isaac Blickstein presents a state-of-the-art overview of the most important hypercoagulable states in women. The nature of this propensity toward intravascular venous or arterial clotting is defined and screening is summarized. Adverse thrombogenic actions in most circumstances are mitigated by anticoagulant therapy. Although thrombophilias usually are discovered when evaluating an untoward event their overall high incidence in healthy individuals leads the practitioner to question the need to prescribe anticoagulants for asymptomatic women. Considerable attention has been directed toward thrombophilias and specific pregnancy complications. More than half of all thromboembolic events during pregnancy are attributable to thrombophilias. Furthermore many thrombophilias are linked with recurrent abortion fetal growth restriction stillbirth and preeclampsia and eclampsia especially the HELLP syndrome. Some thrombophilias also are associated with placental findings of abruption and intervillous or spiral artery thrombosis. The outstanding group of experts in this issue addresses many questions of current clinical interest. Guidelines in this interdisciplinary volume will be 0889-8545 06 - see front matter 2006 Elsevier .

• Sức khỏe phụ nữ
• Chest Physicians
• Peripartum Management
• Perioperative Management
• Anticoagulated Patient
• Venous Thromboembolism
• Acquired Thrombophilia