TAILIEUCHUNG - Báo cáo sinh học: "Durable cytotoxic immune responses against gp120 elicited by recombinant SV40 vectors encoding HIV-1 gp120 ± IL-15"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Durable cytotoxic immune responses against gp120 elicited by recombinant SV40 vectors encoding HIV-1 gp120 ± IL-15 | Genetic Vaccines and Therapy BioMed Central Research Open Access Durable cytotoxic immune responses against gp120 elicited by recombinant SV40 vectors encoding HIV-1 gp120 IL-15 Hayley J McKee1 Patricia Y T sao1 Maria Vera2 Puri Fortes2 and David S Strayer 1 Address Department of Pathology Jefferson Medical College Philadelphia PA USA and 2School of Medicine. Foundation for Applied Medical Research. Division of Gene Therapy. Laboratory of Vector Development. University of Navarra. Irunlarrea 1. 31008. Pamplona. Spain Email Hayley J McKee - Patricia Y T sao - Maria Vera - mvera_luna@ Puri Fortes - pfortes@ David S Strayer - Corresponding author Published 23 August 2004 Received 24 December 2003 Genetic Vaccines and Therapy 2004 2 10 doi 1479-0556-2-10 Accepted 23 August 2004 This article is available from http content 2 1 10 2004 McKee et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A vaccine that elicits durable powerful anti-HIV immunity remains an elusive goal. In these studies we tested whether multiple treatments with viral vector-delivered HIV envelope antigen gp120 with and without IL-15 could help to approach that goal. For this purpose we used recombinant Tag-deleted SV40-derived vectors rSV40s since they do not elicit neutralizing antibody responses and so can be given multiply without loss of transduction efficiency. Methods SV gp120 carried the coding sequences for HIV-1NL4-3 Env and SV mIL-15 carried the cDNA for mouse IL-15. Singly and in combination these two vectors were given monthly to BALB cJ mice. Cytotoxic immunity and cytotoxic memory were tested in .

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