TAILIEUCHUNG - Báo cáo sinh học: "Reprogramming of the non-coding transcriptome during brain development"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Reprogramming of the non-coding transcriptome during brain development. | Valadkhan and Nilsen Journal of Biology 2010 9 5 http content 9 1 5 Journal of Biology MINIREVIEW L__ Reprogramming of the non-coding transcriptome during brain development Saba Valadkhan and Timothy W Nilsen See research article http 1471-2202 11 14 Abstract A recent global analysis of gene expression during the differentiation of neuronal stem cells to neurons and oligodendrocytes indicates a complex pattern of changes in the expression of both protein-coding transcripts and long non-protein-coding RNAs. A fascinating and unexpected outcome of the recent analyses of higher eukaryotic genomes has been the demonstration of pervasive transcription from nonprotein-coding genomic sequences. Indeed the preliminary results of the human ENCODE project indicate that whereas protein-coding sequences occupy less than 2 of the human genome close to 93 of the genome is transcribed into RNA 1 . Although intronic sequences occupy a significant percentage of the non-protein-coding sequences in the genome the majority of the independent non-protein-coding transcripts belong to the group of long non-coding RNAs lncRNAs - RNAs that are more than 200 nucleotides in length and do not appear to have any protein-coding potential 2-4 . A few members of this mysterious and highly understudied group of RNAs have been known for a long time for example the Xist and Air RNAs however the majority of these transcripts have been only recently discovered in high-throughput transcriptome analyses. Furthermore most of them are expressed at low levels and many do not show a high level of sequence conservation. Thus the functional significance of this class of RNAs as a whole is still very poorly understood and subject to debate and speculation. Large non-coding RNAs a novel class of regulators or transcriptional noise Although our understanding of the biological role of this class of RNAs is rudimentary there are several studies Correspondence .

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