TAILIEUCHUNG - Báo cáo sinh học: "Global analysis of X-chromosome dosage compensation"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Global analysis of X-chromosome dosage compensation. | J. Biol. Journal of Biology BioMed Central Research article Open Access Global analysis of X-chromosome dosage compensation Vaijayanti Gupta Michael Parisi David Sturgill Rachel Nuttall Michael Doctolero Olga K Dudko James D Malley P Scott Eastman and Brian Oliver Addresses Laboratory of Cellular and Developmental Biology National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health 50 South Drive Bethesda MD 20892 USA. Incyte Genomics Palo Alto CA 94304 USA. Mathematical and Statistical Computing Laboratory Division of Computational Bioscience Center for Information Technology National Institutes of Health Bethesda MD 20982 USA. Current address Quantum Dot Corporation Hayward CA 94545 USA. Correspondence Vaijayanti Gupta. Email vaijayanti@ Brian Oliver. Email oliver@ Published 16 February 2006 Received 20 June 2005 Journal of Biology 2006 5 3 doi jbiol30 2005 Accepted 7 December 2005 The electronic version of this article is the complete one and can be found online at http content 5 1 3 2006 Gupta et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Drosophila melanogaster females have two X chromosomes and two autosome sets XX AA while males have a single X chromosome and two autosome sets X AA . Drosophila male somatic cells compensate for a single copy of the X chromosome by deploying male-specific-lethal MSL complexes that increase transcription from the X chromosome. Male germ cells lack MSL complexes indicating that either germline X-chromosome dosage compensation is MSL-independent or that germ cells do not carry out dosage compensation. Results To investigate whether dosage compensation occurs in

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