TAILIEUCHUNG - Báo cáo sinh học: "The curious world of apoptotic cell clearance"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The curious world of apoptotic cell clearance. | J. Biol. Journal of Biology BioMed Central Research news The curious world of apoptotic cell clearance Jonathan B Weitzman Published 29 September 2004 Journal of Biology 2004 3 13 The electronic version of this article is the complete one and can be found online at http content 3 4 13 2004 BioMed Central Ltd Analysis of knockout mice has brought into question the previously proposed role of the phosphatidylserine receptor Ptdsr in the clearance of apoptotic cell corpses and has suggested important functions in regulating differentiation and inflammation. Curiouser and curiouser cried Alice when she realized the startling effects of ingesting a small cake on which the words Eat me were beautifully marked in currants 1 . The world of apoptosis research is every bit as wonderful and full of surprises as the Wonderland that Alice discovered. Dying cells display enticing eat me signals and a collection of colorful molecular characters to ensure their digestion. Now in Journal of Biology 2 Andreas Lengeling and colleagues reveal more surprises about the phosphatidylserine receptor Ptdsr molecule that was first cloned as a receptor responsible for the phosphatidylserine-specific clearance of apoptotic cells see The bottom line box for a summary of the work . Body snatching Large numbers of cells die by apoptosis during the development of multicellular organisms see the Background box and many research groups are hunting down the molecular culprits responsible for clearing up the corpses. Apoptotic cells are removed by a process involving recognition and phagocytosis followed by the induction of an active anti-inflammatory response. These events are critical for efficient corpse elimination and to prevent the leakage of potentially cytotoxic or antigenic cellular contents that could elicit an autoimmune response defects in apoptotic cell clearance are The bottom line The gene encoding the phosphatidylserine receptor Ptdsr was originally cloned as the antigen .

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