TAILIEUCHUNG - Báo cáo sinh học: " Genetic parameters for resistance to the Salmonella abortusovis vaccinal strain Rv6 in sheep"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Genetic parameters for resistance to the Salmonella abortusovis vaccinal strain Rv6 in sheep | 199 Genet Sei. Evol. 35 2003 199-217 INRA EDP Sciences 2003 DOI gse 2003004 Original article Genetic parameters for resistance to the Salmonella abortusovis vaccinal strain Rv6 in sheep Carole R. Moreno a Frédéric Lantierc Patricia Berthonc Anne V. Gautier-Bouchardonc Roger Boivinc Isabelle Lantierc Jean-Claude Brunelb Jean-Louis Weisbeckerb Dominique Franqoisa Jacques Bouixa Jean-Michel Elsena a Station d amelioration génétique des animaux Institut national de la recherche agronomique BP 27 31326 Castanet-Tolosan Cedex France b Domaine de Bourges-La Sapinière Institut national de la recherche agronomique 18390 Osmoy France c Laboratoire de pathologie infectieuse et immunologie Institut national de la recherche agronomique BP 1 37380 Nouzilly France Received 30 April 2002 accepted 8 October 2002 Abstract - An experimental population 1216 lambs from 30 sires of the Inra401 sheep was created in an Inra flock to allow QTL detection for susceptibility to Salmonella infection wool and carcass traits. The Inra401 is a sheep composite line developed from two breeds Berrichon du Cher and Romanov. At 113 days of age on average the lambs were inoculated intravenously with io8 Salmonella abortusovis Rv6 vaccinal strain . They were slaughtered 10 days after the inoculation. Several traits were measured at inoculation and or slaughtering to estimate the genetic resistance of the lambs to Salmonella infection specific IgM and IgGl antibody titres body weight loss spleen and pre-scapular node weights and counts of viable Salmonella persisting in these organs. This paper presents a quantitative analysis of the genetic variability of the traits related to salmonellosis susceptibility. The heritabilities of the traits varied between and significantly different from zero . Thus in sheep as well as in other species the determinism of resistance to Salmonella infection is under genetic control. Moreover the correlations between the traits are in agreement with the .

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