TAILIEUCHUNG - Báo cáo khoa học: The PUA domain ) a structural and functional overview

The pseudouridine synthase and archaeosine transglycosylase (PUA) domain is a compact and highly conserved RNA-binding motif that is widespread among diverse types of proteins from the three kingdoms of life. Its three-dimensional architecture is well established, and the structures of several PUA–RNA complexes reveal a common RNA recognition sur-face, but also some versatility in the way in which the motif binds to RNA. | ễFEBS Journal REVIEW ARTICLE The PUA domain - a structural and functional overview Isabel Perez-Arellano1 Jose Gallego2 and Javier Cervera1 1 Molecular Recognition Laboratory Centro de Investigacion Príncipe Felipe Valencia Spain 2 Molecular Structure and Simulation Laboratory Centro de Investigacion Príncipe Felipe Valencia Spain Keywords archaeosine tRNA transglycosylase Cbf5 glutamate 5-kinase H ACA box MCT-1 methyltransferase Nip7 pseudouridine synthase PUA domain translation initiation Correspondence J. Cervera Molecular Recognition Laboratory Centro de Investigacion Príncipe Felipe Avda. Autopista delSaler 16 Valencia 46013 Spain Fax 34 963 289701 Tel 34 963 289680 E-mail cervera@ J. Gallego Molecular Structure and Simulation Laboratory Centro de Investigacion Príncipe Felipe Avda. Autopista delSaler 16 Valencia 46013 Spain Fax 34 963 289701 Tel 34 963 289680 E-mail jgallego@ Received 28 June 2007 revised 3 August 2007 accepted 6 August 2007 doi The pseudouridine synthase and archaeosine transglycosylase PUA domain is a compact and highly conserved RNA-binding motif that is widespread among diverse types of proteins from the three kingdoms of life. Its three-dimensional architecture is well established and the structures of several PUA-RNA complexes reveal a common RNA recognition surface but also some versatility in the way in which the motif binds to RNA. The PUA domain is often part of RNA modification enzymes and ribonucleoproteins but it has also been unexpectedly found fused to enzymes involved in proline biosynthesis where it plays an unknown role. The functional impact of the domain varies with the protein studied ranging from minor to essential effects. PUA motifs are involved in dyskeratosis congenita and cancer pointing to links between RNA metabolism and human diseases. Introduction The PUA domain named after pseudouridine synthase and archaeosine transglycosylase due to its occurrence in several of .

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