TAILIEUCHUNG - Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis

Autophagy and apoptosis play important roles in the development, cellular homeostasis and, especially, oncogenesis of mammals. They may be trig-gered by common upstream signals, resulting in combined autophagy and apoptosis. | IFEBS Journal REVIEW ARTICLE Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis Feifan Zhou Ying Yang and Da Xing MOE Key Laboratory of Laser Life Science Institute of Laser Life Science College of Biophotonics South China Normal university Guangzhou China Keywords apoptosis autophagy Bcl-2 Bcl-xL Beclin 1 Correspondence D. Xing College of Biophotonics South China NormalUniversity Guangzhou 510631 China Fax 86 20 85216052 Tel 86 20 85210089 E-mail xingda@ Website http Received 11 July 2010 revised 27 October 2010 accepted 17 November 2010 Autophagy and apoptosis play important roles in the development cellular homeostasis and especially oncogenesis of mammals. They may be triggered by common upstream signals resulting in combined autophagy and apoptosis. In other instances they may be mutually exclusive. Recent studies have suggested possible molecular mechanisms for crosstalk between autophagy and apoptosis. Bcl-2 and Bcl-xL the well-characterized apoptosis guards appear to be important factors in autophagy inhibiting Beclin 1-mediated autophagy by binding to Beclin 1. In addition Beclin 1 Bcl-2 and Bcl-xL can cooperate with Atg5 or Ca2 to regulate both autophagy and apoptosis. Thus Bcl-2 and Bcl-xL represent a molecular link between autophagy and apoptosis. Here we discuss the possible roles of Bcl-2 and Bcl-xL in apoptosis and autophagy and the crosstalk between them. doi Introduction To become cancerous a cell needs to overcome a number of failsafe mechanisms 1 . It must evade apoptotic and autophagic cell death to survive. Antiapoptotic Bcl-2 family proteins such as Bcl-2 and Bcl-xL are frequently overexpressed in cancers 2 3 . They inhibit apoptosis by binding to Bax or Bak. Bcl-2 and Bcl-xL are also well known for their anti-autophagy abilities 4 . Prolonged nutrient deprivation can invoke autophagy an evolutionarily conserved process for bulk .

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