TAILIEUCHUNG - Chapter 078. Prevention and Early Detection of Cancer (Part 2)

Physical Activity Physical activity is associated with a decreased risk of colon and breast cancer. A variety of mechanisms have been proposed. However, such studies are prone to confounding factors such as recall bias, association of exercise with other health-related practices, and effects of preclinical cancers on exercise habits (reverse causality). Recommending adults to engage in at least 30 min of vigorous activity for ≥3 days a week is good health advice, though its effects on cancer incidence are unproven. Diet Modification International epidemiologic studies suggest that diets high in fat are associated with increased risk for cancers of the breast,. | Chapter 078. Prevention and Early Detection of Cancer Part 2 Physical Activity Physical activity is associated with a decreased risk of colon and breast cancer. A variety of mechanisms have been proposed. However such studies are prone to confounding factors such as recall bias association of exercise with other health-related practices and effects of preclinical cancers on exercise habits reverse causality . Recommending adults to engage in at least 30 min of vigorous activity for 3 days a week is good health advice though its effects on cancer incidence are unproven. Diet Modification International epidemiologic studies suggest that diets high in fat are associated with increased risk for cancers of the breast colon prostate and endometrium. These cancers have their highest incidence and mortalities in western culture where fat comprises an average of 40-45 of the total calories consumed. In populations at low risk for these cancers fat accounts for 20 of dietary calories. Despite correlations dietary fat has not been proven to cause cancer. Casecontrol and cohort epidemiologic studies give conflicting results. In addition diet is a highly complex exposure to many nutrients and chemicals. Low-fat diets are associated with many dietary changes beyond simple subtraction of fat. Other lifestyle changes are also associated with adherence to a low-fat diet. The Women s Intervention Nutrition Study WINS evaluated the effects of low-fat diet on breast cancer recurrence in previously treated postmenopausal breast cancer patients. Breast cancer patients mean age 62 years were randomly assigned to a standard diet 40 fat or a low-fat diet 26 fat . At 5 years breast cancer had recurred in of women in the low-fat diet group compared to of women on the standard diet. In observational studies dietary fiber lowers the risk of colonic polyps and invasive cancer of the colon. However cancer protective effects of increasing fiber and lowering dietary fat have not been .

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