TAILIEUCHUNG - Báo cáo y học: "Unexpected elevated alanine aminotransferase, asparte aminotransferase levels and hepatitis E virus infection among persons who work with pigs in accra, ghana"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Unexpected elevated alanine aminotransferase, asparte aminotransferase levels and hepatitis E virus infection among persons who work with pigs in accra, ghana | Adjei et al. Virology Journal 2010 7 336 http content 7 1 336 VIROLOGY JOURNAL RESEARCH Open Access Unexpected elevated alanine aminotransferase asparte aminotransferase levels and hepatitis E virus infection among persons who work with pigs in accra ghana A ndA A rHc Vv Tdttdx 1 caHio T A i ocd2 ClomofV Adi i-hCwn mtl3 II ilĩi IC A K Ilnc ilci2 cd oi md T i l .irto 4 Andrew A Adjei Ido Tettey John I Aviyase Clement ntiu Gyaiifi Julius A Mingle tumunu I iNditey Abstract Background Several studies have suggested that elevated serum dldnine aminotransferase ALT and asparte aminotransferase AST may be markers of hepatitis E virus HEV infection. Thus individuals with elevated ALT and AST may have ongoing subclinical infection of HEV. We estimated the prevalence of anti-HEV antibodies and serum ALT and AST levels among persons who work with pigs in Accra Ghana. Results Three hundred and fifty- persons who work with pigs provided blood samples for unlinked anonymous testing for the presence of antibodies to HEV ALT and AST levels. The median age of participants was years range 15-70 years . HEV seroprevelance was . Anti-HEV IgG was detected in while anti-HEV IgM was detected in of the persons who tested positive. On multivariate analysis the independent determinants of HEV infection were being employed on the farm for less than six months odds ratio OR 95 confidence interval 95 CI having piped water in the household and or on the farm OR 95 CI and consumption of alcohol OR 95 CI . Levels 3x the expected maximum were found for both ALT and AST among individuals who tested positive for anti-HEV IgG ALT U L AST U L and anti-HEV IgM ALT u l AST U L . Conclusion Consistent with similar studies worldwide the results of our studies revealed a high prevalence of HEV infection ALT and AST values in pig handlers. Introduction Hepatitis

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