TAILIEUCHUNG - ABSORPTION AND DRUG DEVELOPMENT

This book is written for the practicing pharmaceutical scientist involved in absorption–distribution–metabolism–excretion (ADME) measurements who needs to communicate with medicinal chemists persuasively, so that newly synthesized molecules will be more ‘‘drug-like.’’ ADME is all about ‘‘a day in the life of a drug molecule’’ (absorption, distribution, metabolism, and excretion). Specifically, this book attempts to describe the state of the art in measurement of ionization constants (pKa), oil–water partition coefficients (log P/log D), solubility, and permeability (artificial phospholipid membrane barriers). Permeability is covered in considerable detail, based on a newly developed methodology known as parallel artificial membrane permeability assay (PAMPA) | ABSORPTION AND DRUG DEVELOPMENT ABSORPTION AND DRUG DEVELOPMENT Solubility Permeability and Charge State ALEX AVDEEF pION Inc. WI LEY- INTERSCIENCE AJOHN WILEY SONS INC. PUBLICATION Copyright 2003 by John Wiley Sons Inc. All rights reserved. Published by John Wiley Sons Inc. Hoboken New Jersey. Published simultaneously in Canada. No part of this publication may be reproduced stored in a retrieval system or transmitted in any form or by any means electronic mechanical photocopying recording scanning or otherwise except as permitted under Section 107 or 108 of the 1976 United States Copyright Act without either the prior written permission of the Publisher or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center Inc. 222 Rosewood Drive Danvers MA 01923 978-750-8400 fax 978-750-4470 or on the web at . Requests to the Publisher for permission should be addressed to the Permissions Department John Wiley Sons Inc. 111 River Street Hoboken NJ 07030 201 748-6011 fax 201 748-6008 e-mail permreq@. Limit of Liability Disclaimer of Warranty While the publisher and author have used their best efforts in preparing this book they make no representations or warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives or written sales materials. The advice and strategies contained herein may not be suitable for your situation. You should consult with a professional where appropriate. Neither the publisher nor author shall be liable for any loss of profit or any other commercial damages including but not limited to special incidental consequential or other damages. For general information on our other products and services please contact our Customer Care Department within the . at 877-762-2974 outside the . at .

• Y học thường thức
• capillary electrophoresis
• dodecylcarboxylic acid
• cyclic votammetry
• extrusion technique
• glycerol monooleate
• optical density
• Ultraviolet detection
• Organic acids
• Rapid capillary electrophoresis method
• Lactic acids
• Chromatography A
• Mass spectrometry
• Capillary zone electrophoresis
• Post translational modifications
• Simultaneous determination
• Simultaneous determination of paracetamol
• Diclofenac in pharmaceutical formulations
• Công nghệ hóa
• Capillary electrophoresis system
• Electrochemical detection
• Hóa lý
• Hệ thống điện di mao
• Micellar Electrokinetic Capillary Chromatography
• Tạp chí phân tích
• Ammonium and potassium extracted
• Soil samples by capillary electrophoresis
• Capacitively coupled contactless conductivity detection
• Separation of recombinant erythropoietin isoforms by capillary electrophoresis
• Recombinant erythropoietin isoforms
• EPO decides biological activity of products
• Distinguish recombinant products
• RNA integrity score
• Optical measurement
• Ribosomal RNA
• Micro RNA
• Chemical science
• Biological science
• Response surface methodology
• Central composite design
• Journal of Chemistry
• Sample stacking
• Thiocyanate derivatives
• Ultra heat treated (UHT)
• Contactless conductivity detector
• Pomegranate juice
• Propanesulfonic acid
• Ethylenediaminetetraacetic acid
• Pharmaceutical gel
• Reversed phase HPLC methods
• Phosphate concentration
• Limit of quantification (LOQ)
• Human plasma
• Type 2 diabetes
• Ranitidine hydrochloride
• Biological fluids
• Insulin analogues
• Successive multiple ionic polymer layer
• Chiral separation
• Enantiomer migration order
• Supramolecular interactions
• Electromembrane extraction
• Sample preparation
• Sample enrichment
• Contrast agent
• Polyvinyl alcohol microbubbles
• UV area imaging detector
• High performance liquid chromatography
• Food colorants
• Food preservatives
• Sports drinks
• Spirodela polyrhiza
• Electrokinetic chromatography
• Nanoflow interface
• Amino acids
• Multisegment injection capillary electrophoresis
• Colorectal cancer
• Background electrolyte
• Microfluidic Breadboard Approach
• Sheathless Interface
• Electrodeless interface configuration
• Internal standard
• Solvent mixture
• Aqueous buffers
• Capacitively coupled
• Food control
• General conclusions
• Food analysis
• Biogenic amines
• Extracellular vesicles
• Outer membrane vesicles
• DNA fingerprinting
• Automated chip capillary electrophoresis
• Band matching
• Gel sample distortion
• Pattern recognition