TAILIEUCHUNG - Báo cáo khoa học: Oligomannose-coated liposomes efficiently induce human T-cell leukemia virus-1-specific cytotoxic T lymphocytes without adjuvant

Human T-cell leukemia virus-1 (HTLV-1) causes adult T-cell leuke-mia⁄lymphoma, which is an aggressive peripheral T-cell neoplasm. Insuffi-cient T-cell response to HTLV-1 is a potential risk factor in adult T-cell leukemia⁄lymphoma. | IFEBS Journal Oligomannose-coated liposomes efficiently induce human T-cell leukemia virus-1-specific cytotoxic T lymphocytes without adjuvant Tomohiro Kozako1 2 Shinya Hirata3 Yoshitaka Shimizu4 Yuichiro Satoh4 Makoto Yoshimitsu5 Yohann White1 Francois Lemonnier6 Hiroshi Shimeno2 Shinji Soeda2 and Naomichi Arima1 1 Division of Hematology and Immunology Center for Chronic ViralDiseases Graduate Schoolof Medicaland DentalSciences Kagoshima University Japan 2 Department of Biochemistry Faculty of PharmaceuticalSciences Fukuoka University Japan 3 Department of Immunogenetics Graduate Schoolof MedicalSciences Kumamoto University Japan 4 BioMedCore Inc. Yokohama Kanagawa Japan 5 Department of Hematology and Immunology Kagoshima University Hospital Japan 6 Unite d Immunite Cellulaire Antivirale Institut Pasteur Paris France Keywords adult T-cellleukemia lymphoma cytotoxic T lymphocytes human T-cellleukemia virus-1 oligomannose liposome vaccines Correspondence T. Kozako Department of Biochemistry Faculty of Pharmaceutical Sciences Fukuoka University 8-19-1 Nanakuma Jonan-ku Fukuoka 814-0180 Japan Fax 81 92 862 4431 Tel 81 92 871 6631 E-mail kozako@ N. Arima Division of Host Response Center for Chronic Viral Diseases Graduate School of Medical and Dental Sciences Kagoshima University 8-35-1 Sakuragaoka Kagoshima 890-8544 Japan Fax 81 99 275 5947 Tel 81 99 275 5934 E-mail nao@ Received 11 October 2010 revised 8 February 2011 accepted 16 February 2011 doi Human T-cell leukemia virus-1 HTLV-1 causes adult T-cell leuke-mia lymphoma which is an aggressive peripheral T-cell neoplasm. Insufficient T-cell response to HTLV-1 is a potential risk factor in adult T-cell leukemia lymphoma. Efficient induction of antigen-specific cytotoxic T lymphocytes is important for immunological suppression of virus-infected cell proliferation and oncogenesis but efficient induction of antigen-specific cytotoxic T lymphocytes

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