TAILIEUCHUNG - Báo cáo khoa học: Dopamine D4 receptor oligomerization – contribution to receptor biogenesis

Dopamine D4receptors (D4Rs) are G protein-coupled receptors that play a role in attention and cognition. In the present study, we investigated the dimerization properties of this receptor. Western blot analysis of the human , and revealed the presence of higher molecular weight immunoreactive bands, which might indicate the formation of receptor dimers and multimers. | BFEBS Journal Dopamine D4 receptor oligomerization - contribution to receptor biogenesis Kathleen Van Craenenbroeck1 Dasiel O. Borroto-Escuela2 Wilber Romero-Fernandez2 If a m 11a o Ixi zt zt f Q Izo 1 Pi zt zt r R f n d 1 I I 1 p nn rirm I in nr one 1 Pzt zt r y QnhAQnQrl QK1 1 i zt 11 El iva2 Kamila Okieieiska lieiei Roiidou Beatrice Linieiiiiaiis reiei vaniioeiiackei I Kjell Fuxe Francisco Ciruela3 and Guy Haegeman1 1 Laboratory of Eukaryotic Gene Expression and SignalTransduction LEGEST Ghent University Hospital UZ Gent Belgium 2 Department of Neuroscience Karolinska Institutet Stockholm Sweden 3 Departament Patologia i Terapeutica Experimental Facultat de Medicina Unitat de Farmacologia IDIBELL-Universitat de Barcelona L Hospitalet de Llobregat Barcelona Spain Keywords bioluminescence resonance energy transfer dimerization dopamine D4 receptor G protein-coupled receptors receptor biogenesis Correspondence K. Van Craenenbroeck Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST Ghent University-UGent KL Ledeganckstraat 35 9000 Gent Belgium Fax 32 0 9 264 53 04 Tel 32 0 9 264 51 35 E-mail Present addresses Center for MedicalGenetics Ghent CMGG Ghent University Hospital - UZ Gent Belgium ỊActoGeniX Technologiepark 4 Zwijnaarde Belgium Received 4 August 2010 revised 23 January 2011 accepted 10 February 2011 doi Dopamine D4 receptors D4Rs are G protein-coupled receptors that play a role in attention and cognition. In the present study we investigated the dimerization properties of this receptor. Western blot analysis of the human and revealed the presence of higher molecular weight immunoreactive bands which might indicate the formation of receptor dimers and multimers. Homo- and heterodimerization of the receptors was confirmed by co-immunoprecipitation and bioluminescence resonance energy transfer studies. Although dimerization of a large number of G .

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