TAILIEUCHUNG - Báo cáo khoa học: a-enolase: a promising therapeutic and diagnostic tumor target

a-enolase (ENOA) is a metabolic enzyme involved in the synthesis of pyru-vate. It also acts as a plasminogen receptor and thus mediates activation of plasmin and extracellular matrix degradation. In tumor cells, EMOAis upregulated and supports anaerobic proliferation (Warburg effect), it is expressed at the cell surface, where it promotes cancer invasion | yFEBS Journal REVIEW ARTICLE a-enolase a promising therapeutic and diagnostic tumor target Michela Capello Sammy Ferri-Borgogno Paola Cappello and Francesco Novelli Department of Medicine and ExperimentalOncology Center for ExperimentalResearch and MedicalStudies CeRMS San Giovanni Battista Hospital University of Turin Italy Keywords a-enolase cancer immune response post-translationalmodifications tumor-associated antigen Correspondence F. Novelli Center for ExperimentalResearch and MedicalStudies CeRMS San Giovanni Battista Hospital Via Cherasco 15 10126 Turin Italy Fax 39 011 633 6887 Tel 39 011 633 4463 E-mail Received 5 November 2010 revised 19 January 2011 accepted 21 January 2011 doi a-enolase ENOA is a metabolic enzyme involved in the synthesis of pyruvate. It also acts as a plasminogen receptor and thus mediates activation of plasmin and extracellular matrix degradation. In tumor cells ENOA is upregulated and supports anaerobic proliferation Warburg effect it is expressed at the cell surface where it promotes cancer invasion and is subjected to a specific array of post-translational modifications namely acetylation methylation and phosphorylation. Both ENOA overexpression and its post-translational modifications could be of diagnostic and prognostic value in cancer. This review will discuss recent information on the biochemical proteomics and immunological characterization of ENOA particularly its ability to trigger a specific humoral and cellular immune response. In our opinion this information can pave the way for effective new therapeutic and diagnostic strategies to counteract the growth of the most aggressive human disease. Introduction Enolase is a metalloenzyme that catalyzes the dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate in the second half of the glycolytic pathway. In the reverse reaction anabolic pathway which occurs during gluconeogenesis the enzyme catalyzes the hydration

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