TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 158

Pharmaceutical Substances Syntheses, Patents, Applications - Part 158. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Pecilocin P 1571 Pecilocin ATC D01AA04 Use fungicidal antibiotic RN 19504-77-9 MF C17H25NO3 MW EINECS 243-116-9 LDW 320 mg kg M . CN R- E E E -1 - 8-hydroxy-6-methyl-1 -oxo-2 4 6-dodecatrienyl -2-pyrrolidinone From culture of Paecilomyces varioti Bainier var. antibioticus. Reference s GB 866 425 Japan Antibiotics Research Assoc. appl. . Formulation s ointment 3000 iu g topical sol. 1500 iu ml Trade Name s D Supral Basotherm wfm GB Variotin Leo wfrtt F Leofungine Leo wfm J Variotin Nippon Kayaku Pefloxacin atc joimao3 Use antibiotic gyrase inhibitor RN 70458-92-3 MF C 7H20FN3O3 MW EINECS 274-611-8 LD50 225 mg kg M . 4 g kg M . CN 1 -ethyl-6-fluoro-1 4-dihydro-7- 4-methyl-1 -piperazinyl -4-oxo-3-quinolinecarboxylic acid monomesylate RN 70458-95-6 MF Cl7H20FN3O3 CH4O3S MW EINECS 274-613-9 LD50 225 mg kg M . 1 g kg M . 2500 mg kg R . 3-chloro-4- diethyl ethoxy- fluoroaniline methylenemalonate ethyl 7-chloro-6-fluoro- 4-hydroxyquinoline- 3-carboxylate l- - CH3 K2CO3 ethyl iodide H2O H II 1572 P Pemirolast II N-methylpiperozine Reference s US 4 292 317 Roger Bellon appl. GB-prior. . DOS 2 840 910 Lab. Roger Bellon appl. GB-prior. . Gouffon G. et al. C. R. Hebd. Seances Acad. Sci. COREAF 292 1981 . Formulation s f. c. tabl. 400 mg inj. sol. 400 mg 125 ml 400 mg 5 ml as mesylate Trade Name s D Peflacin Rhône-Poulenc F Peflazine Bellon Rhône- I Rorer Poulenc 1985 Peflacin Rhône-Poulenc Pharma Pcflox Forment Pemirolast ATC R03 Use antiallergic RN 69372-19-6 MF Cl0H8N6O MW CN 9 methyl-3- l Ltetrazol-5-yl -4 7-pyrido l 2-ci pyrimidin-4-one potassium salt RN 100299-08-9 MF Cl0H7KN6O MW LD50 220 mg kg M . 1185 mg kg M . 372 mg kg R . 687 mg kg R . toluene A ----------- o ch3 ethyl 2-cyano-3- 3-methylpyridin-2-ylamino acrylate II 2-omino-3- ethyl 2-cyano-3- methyl- ethaxyacrylate pyridine 1 NoNj AtClj sodium azide 0 N-N Pemirolast Pemoline P 1573 c2H50H _ I

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