TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 76

Pharmaceutical Substances Syntheses, Patents, Applications - Part 76. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Epinastine hydrochloride E 751 Formulation s tabl. 5 mg Trade Name s D Stimovul Organon wfm I Stimovul Organon Italia J Stimovul Ravasini Epinastine hydrochloride WAL-801CL ATC R06AX24 Use antihistaminic RN 108929-04-0 MF C1 1H15N3 HC1 MW LD5 17 mg kg R . 192 mg kg R . CN i-dibenzlc limidazolES-aJazepin-S-amine monohydrochloride epinastine RN 80012-43-7 MF C16H 5N3 MW 6-cMoro-11H- I DMSO 60 C ------------ 6-cyano-11 H-dibenz b e azepine AIH3 THF ----------- II Br CN 1. ethanol THF 2. NaOH 3. HCI 6-aminomethyl- cyanogen 6J1-dihydro-5H- bromide dibenz b e azepine 11 6- phthalimidomethyl - 11 H-dibenz b e ozepine N2H4 H2O NoOH 110 C ------------- II 6- phthalimidomethyl - 6 11-dihydro-5H-dibenz b e azepine n i 1. Br2 10-15 C 2 H n jU 3. NoOH --------------- 2. N-methyl- benzylamine Epinastine hydrochloride Epinastine 752 E Epinephrine Reference s a DE 3 008 944 Boehringer Ing. appl. D-prior. . starting material Hunziker E. et al. Helv. Chim. Acta HCACAV 49 11 1433 1966 50 1 245 1967 . b EP496 306 Boehringer Ing. appl. D-prior. . composition with PAF-antagonists WO 8 910 143 Schering Corp. appl. USA-prior. . Formulation s tabl. 10 mg 20 mg Trade Name s J Alesion Nippon Boehringer Ing. Sakyo Epinephrine ATC A01AD01 B02BC09 C01CA24 Adrenaline R03AA01 S01EA01 Use sympathomimetic vasoconstrictor RN 51-43-4 MF C9HI3NO3 MW EINECS 200-098-7 LD5 217 pg kg M . 150 fJ-g kg R . 100 pg kg dog . . CN R -4- l-hydroxy-2- methylamino ethyl -l 2-benzenediol hydrochloride RN 55-31-2 MF C9H13NO3 HC1 MW EINECS 200-230-3 LD5 140 pg kg M . 24 mg kg R . tartrate 1 1 RN 51-42-3 MF CyH13NO3 C4H6O6 MW EINECS 200-097-1 LD50 1780 pg kg M . 4 mg kg M . 82 pg kg R . OH OH h3c nh2 ----- Cl 2-chloro-3 4 - methylamine dihydroxy-ocetaphenone OH 3 4 -dihydraxy- 2-methylamino-ocetophenone DL-epinephrine I -tartaric acid I -------------------- OH .

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