TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 62

Pharmaceutical Substances Syntheses, Patents, Applications - Part 62. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | F Dexchlorpheniramine D 611 t -brompheniromíne q. V. rocemate resolution with D phenylsuccinic acid -------- --------------- Reference s US 3 030 371 L. A. Walter appl. 1958 . US 3061 517 Schering Corp. prior. . Formulation s tabl. 2 mg Trade Name s USA Disobrom Geneva Dexchlorpheniramine ATC R06AB02 Use antihistaminic RN 25523-97-1 MF C16H 9C1N2 MW EINECS 247-073-7 CN S -Y- 4-chlorophenyl -Af A -dimethyl-2-pyridinepropanamine maleate 1 1 RN 2438-32-6 MF C16H19C1N2 C4H4O4 MW EINECS 219-450-6 LDW 28 mg kg M . 189 mg kg M . 267 mg kg R . D-phenylsuccinic acid ------------------ Reference s GB 834 984 Scherico appl. USA-prior. . US 3 030 371 L. H. Walter appl. . US 3 061 517 Schering Corp. prior. . Formulation s drg. 6 mg tabl. 2 mg Trade Name s D Celestamine Essex -comb. Polaronil Byk Essex F Celestamine Schering- Plough as meleate Polaramine Schering-Plough as maleate I Polaramin Schering- Plough J Polaramine Schering- Shionogi USA Baylarmine Bay wfm 612 D Dexfenfluramine Dexchlor Repeat Action Poladex . wfm Polaramine Schering j Schein wfm wfm Dexfenfluramine atc-. A08AA04 j Use antiobesity S-enantiomer of fenfluramine RN 3239-44-9 MF C12H16F3N MW j LD50 115 mg kg R . CN 5 -lV-ethyl-a-methyl-3- trifluoromethyl benzeneethanamine i hydrochloride RN 3239-45-0 MF CI2H16F3N HC1 MW EINECS 221-806-0 fenfluramine racemate 1. D-dibenzayltcrtcric acid 2. 1R 3S - -campharîc acid H3c CH-j HOOC o XvCH3 _ COOH I 1. crystallization 2. NaOH Reference s DE 1 293 774 Sience-Union et Cie. Soc. Franç. de Recherche Médicale appl. USA-prior. . GB 1 078 186 Sience-Union et Cie. Soc. Franç. de Recherche Médicale appl. USA-prior. . medical use as antidepressant EP 2 531 146 R. J. Wurtman et al. USA-prior. . medical use for intermittent carbohydrate craving EP 53 175 J. et al. appl. .

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