TAILIEUCHUNG - Encyclopedia Of Animal Science - Q

Từ điển khoa học động vật vần Q | Quantitative Trait Loci QTL Morris Soller Ehud Lipkin The Hebrew University of Jerusalem Jerusalem Israel INTRODUCTION Most traits of agricultural importance such as growth rate and body composition milk yield and composition and egg number and quality show a continuous distribution of quantitative trait measurements in a population. Such traits are termed quantitative traits in contrast to Mendelian traits which typically are found in a limited number of qualitatively different forms in a population . presence or absence of horns brown or black coat color . Genetic variation in a quantitative trait is generally attributed to allelic variation at a number of genes in contrast to the one or two genes generally found sufficient to explain genetic variation in a Mendelian trait. Moreover quantitative trait expression is much affected by environmental variables again in contrast to Mende-lian traits which are generally little affected by environment. Consequently for quantitative traits the relationship between genotype and phenotype is complex and the genotype of an individual cannot be inferred from its phenotype or that of its relatives. Instead the various genes affecting a quantitative trait are individuated by mapping them to specific chromosomal locations loci . For this reason the term quantitative trait loci or QTL was proposed for the individual mapped genetic factors affecting quantitative trait value. Mapping the QTL responsible for genetic variation in traits of agricultural importance and using the map locations to identify the actual genes involved is a major challenge for animal genetics. Success will provide powerful tools for understanding the physiology of trait variation and for genetic improvement of animal stocks. Consequently showing that a QTL is found in the near vicinity of a specific marker termed linked to the marker is equivalent to mapping the QTL to the location of the marker. Thus a prior requirement for QTL mapping is the .

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